Clinical Characteristics of Mother-Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population

Sanket Jani, Suzanne M. Jacques, Faisal Qureshi, Girija Natarajan, Sujit Bajaj, Pradeep Velumula, Cindy Agu, Monika Bajaj

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective In this currently evolving coronavirus disease 2019 (COVID-19) pandemic, the evidence is scarce about the impact of COVID-19 infection on women in labor and neonates in an inner city African-Americans (AA) population. The objective of this study was to evaluate the clinical outcomes and placental pathology in mother-infant dyads in COVID-19 cases. Study Design Retrospective chart review was conducted on 34 COVID-19 positive mother-infant dyads to study their baseline characteristics and outcomes. Placental pathology was reviewed by two perinatal pathologists. Results COVID-19 was noted in 3% of pregnant women who delivered in our institution. The majority (82%) of them were asymptomatic. Out of the four mothers who were symptomatic, only three (9%) required supplemental oxygen. None of them required invasive ventilation. All the neonates tested negative for COVID-19 at 24 hours of age. There were no gross or microscopic pathological abnormalities detected that could be definitely associated with any COVID-19 related complications during pregnancy in any of the 34 placentas. Conclusion COVID-19 does not appear to increase morbidity and mortality among pregnant women and their neonates in a predominantly AA population. Our study did not find any evidence of vertical transmission of COVID-19 infection nor any specific findings on placental pathology. Key Points Majority of women infected by coronavirus disease 2019 (COVID-19) during labor were asymptomatic. None of the newborns tested positive for COVID-19 at 24 hours of age. Placental pathology findings were nonspecific in COVID-19 mothers.

Original languageEnglish
Pages (from-to)E15-E20
JournalAJP Reports
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2021

Keywords

  • Covid-19
  • perinatal effect
  • placenta pathology
  • vertical transmission

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