Objective: To investigate the significance of ultrasonic detection of fetal nuchal fold (NF) thickening in screening trisomy 21 during the second trimester. Methods: Amniocentesis and cordocentesis were performed in pregnant women with indications of prenatal diagnosis, and the chromosome karyotype analysis was performed. The detection rate of trisomy 21 in fetus with ultrasonic manifestation of NF thickening was calculated. Meanwhile, the relationship between fetal NF thickening and the occurrence of trisomy 21 was observed. Results: The chromosome karyotype analysis of the pregnant women who underwent amniocentesis showed that there were 18 fetus with NF thickening. Trisomy 21 was found in 5 fetus among them, the detection rate was 27.78%. The detection rate of trisomy 21 detected hinted by fetal NF thickening was higher than that of other abnormal ultrasonic manifestations (P=0.015). The chromosome karyotype analysis of the pregnant women who underwent cordocentesis showed that there were 12 fetus with NF thickening, among which 1 of trisomy 21 was detected, the detection rate of trisomy 21 was 8.33%. Conclusion: Fetal NF thickening is an effective soft marker of ultrasonography in screening trisomy 21 during the second trimester.
|Number of pages||4|
|Journal||Chinese Journal of Medical Imaging Technology|
|State||Published - Dec 2010|
- Down syndrome
- Ultrasonography, prenatal