Clinical Significances of Anti-Collagen Type I and Type III Antibodies in Antibody-Mediated Rejection

Sehoon Park, Seung Hee Yang, Jiyeon Kim, Semin Cho, Jaeseok Yang, Sang Il Min, Jongwon Ha, Chang Wook Jeong, Seong Hee Bhoo, Yong Chul Kim, Dong Ki Kim, Kook Hwan Oh, Kwon Wook Joo, Yon Su Kim, Kyung Chul Moon, Eun Young Song, Hajeong Lee

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2 Scopus citations


It is important to determine the clinical significance of non-human leukocyte antigen (HLA) antibodies and their association with antibody-mediated rejection (ABMR) of kidney allografts. We collected post-transplant sera from 68 ABMR patients, 67 T-cell mediated rejection (TCMR) patients, and 83 control subjects without rejection, and determined the titers of 39 non-HLA antibodies including antibodies for angiotensin II receptor type I and MICA. We compared all these non-HLA antibody titers among the study groups. Then, we investigated their association with the risk of death-censored graft failure in ABMR cases. Among the antibodies evaluated, anti-collagen type I (p = 0.001) and type III (p < 0.001) antibody titers were significantly higher in ABMR cases than in both TCMR cases and no-rejection controls. Both anti-collagen type I [per 1 standard deviation (SD), adjusted odds ratio (OR), 11.72 (2.73–76.30)] and type III [per 1 SD, adjusted OR, 6.22 (1.91–31.75)] antibodies were significantly associated with the presence of ABMR. Among ABMR cases, a higher level of anti-collagen type I [per 1 SD, adjusted hazard ratio (HR), 1.90 (1.32–2.75)] or type III per 1 SD, [adjusted HR, 1.57 (1.15–2.16)] antibody was associated with a higher risk of death-censored graft failure. In conclusion, post-transplant anti-collagen type I and type III antibodies may be novel non-HLA antibodies related to ABMR of kidney allografts.

Original languageEnglish
Article number10099
JournalTransplant International
StatePublished - May 11 2022
Externally publishedYes


  • antibody-mediated rejection
  • graft failure
  • kidney
  • kidney transplantation
  • non-HLA antibody


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