Cognitive Dysfunction and Other Comorbidities: The Relationship of Epilepsy to Other Conditions/Disorders

A. F. Luat; D. C. Chugani

doi:10.1016/B978-012373961-2.00343-X

Cognitive Dysfunction and Other Comorbidities: The Relationship of Epilepsy to Other Conditions/Disorders

A. F. Luat, D. C. Chugani

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Epilepsy occurs in a number of neurodevelopmental disorders. This observation suggests the existence of a set of common etiological and neuropathological pathways involved in a complex interaction of genetic, neurobiological, and developmental factors. Many neurodevelopmental disorders originate from the disruption of certain stages of brain development, which subsequently result in the alteration of synaptic function and/or the formation of dysplastic neurons - which, in turn, give rise to hyperexcitable networks that increases seizure susceptibility. In this review, we discuss possible mechanistic connections between epilepsy and autism, particularly in two genetic/developmental disorders - Rett syndrome and tuberous sclerosis complex.

Original language	English
Title of host publication	Encyclopedia of Basic Epilepsy Research
Publisher	Elsevier Inc.
Pages	181-185
Number of pages	5
ISBN (Print)	9780123739612
DOIs	https://doi.org/10.1016/B978-012373961-2.00343-X
State	Published - Jan 1 2009

Keywords

Autism
Dysplastic neurons
Epilepsy
Migration
Neurodevelopmental disorders
Neurotransmitters
Rett syndrome
Synaptic function
Tuberous sclerosis complex

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10.1016/B978-012373961-2.00343-X

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KW - Migration

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KW - Neurotransmitters

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KW - Synaptic function

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Cognitive Dysfunction and Other Comorbidities: The Relationship of Epilepsy to Other Conditions/Disorders

Abstract

Keywords

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