Cognitive Dysfunction and Other Comorbidities: The Relationship of Epilepsy to Other Conditions/Disorders

A. F. Luat, D. C. Chugani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Epilepsy occurs in a number of neurodevelopmental disorders. This observation suggests the existence of a set of common etiological and neuropathological pathways involved in a complex interaction of genetic, neurobiological, and developmental factors. Many neurodevelopmental disorders originate from the disruption of certain stages of brain development, which subsequently result in the alteration of synaptic function and/or the formation of dysplastic neurons - which, in turn, give rise to hyperexcitable networks that increases seizure susceptibility. In this review, we discuss possible mechanistic connections between epilepsy and autism, particularly in two genetic/developmental disorders - Rett syndrome and tuberous sclerosis complex.

Original languageEnglish
Title of host publicationEncyclopedia of Basic Epilepsy Research
PublisherElsevier Inc.
Number of pages5
ISBN (Print)9780123739612
StatePublished - Jan 1 2009


  • Autism
  • Dysplastic neurons
  • Epilepsy
  • Migration
  • Neurodevelopmental disorders
  • Neurotransmitters
  • Rett syndrome
  • Synaptic function
  • Tuberous sclerosis complex


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