Combinatorial Development and In Vitro Characterization of the Quaternary Zr–Ti–X–Y (X–Y = Cu–Ag/Co–Ni) Metallic Glass for Prospective Bioimplants

Akib Jabed, Zia Ur Rahman, Muhammad Mudasser Khan, Waseem Haider, Ishraq Shabib

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The prospect of Zr-based metallic glasses (MGs) in achieving a combination of properties, such as excellent electrochemical properties and extended biocompatibility, has been studied in this work. The combinatorial method (magnetron co-sputtering) has been adopted to fabricate two novel quaternary MG systems (Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11) with optimized compositions. The structural analysis has been performed by the grazing incidence x-ray diffraction and high-resolution transmission electron microscopy to affirm the disordered structure of the MG systems. The electrochemical analysis demonstrates lower corrosion- (0.10 and 0.04 μA cm−2), and passive (2.93 and 1.88 μA cm−2) current densities of the MGs. In addition, the MGs are found to have higher charge transfer resistance (4.70 and 7.86 MΩ cm2) compared to the 316L stainless steel (SS) (0.15 MΩ cm2) and cp-Ti (0.53 MΩ cm2). The electrochemical features are indicative towards higher corrosion-resistance capabilities of Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs to prevent adverse biological reactions. Additionally, the cell proliferation analysis manifests higher cell proliferation on the Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs for the MC3T3-E1 preosteoblast cells. Besides, the MTS assay analysis strengthens the prediction of cytocompatibility of the MGs. The integration of such unique properties makes these MG systems ideal candidates for biomedical implants.

Original languageEnglish
Article number1900726
JournalAdvanced Engineering Materials
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2019

Keywords

  • cell proliferation
  • cytotoxicity analysis
  • electrochemical properties
  • metallic glass

Fingerprint

Dive into the research topics of 'Combinatorial Development and In Vitro Characterization of the Quaternary Zr–Ti–X–Y (X–Y = Cu–Ag/Co–Ni) Metallic Glass for Prospective Bioimplants'. Together they form a unique fingerprint.

Cite this