Comparing patient characteristics and outcomes in type 1 versus type 2 diabetes with diabetic ketoacidosis: A review and a propensity-matched nationwide analysis

Hafeez Shaka, Farah Wani, Zain El-Amir, Dushyant Singh Dahiya, Jagmeet Singh, Ehizogie Edigin, Precious Eseaton, Asim Kichloo

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetic ketoacidosis (DKA) is a known complication of patients with type 1 diabetes mellitus (T1DM), but less common in type 2 diabetes mellitus (T2DM). The aim of this study was to compare the outcomes of patients admitted to the hospital with DKA in T1DM versus T2DM. This was a population-based, retrospective, cohort study using data from the Nationwide Inpatient Sample. The group of patients hospitalized for DKA was divided based on a secondary diagnosis of either T1DM or T2DM. The primary outcome was inpatient mortality, and the secondary outcomes were rate of complications, length of hospital stay (LOS) and total hospital charge (THC). The inpatient mortality for DKA was 0.27% (650 patients). In T2DM, the adjusted OR (aOR) for mortality was 2.13 (95% CI 1.38 to 3.28, p=0.001) with adjusted increase in mean THC of $6035 (95% CI 4420 to 7652, p<0.001) and mean LOS of 0.5 day (95% CI 0.3 to 0.6, p<0.001) compared with T1DM. Patients with T2DM had significantly higher odds of having septic shock (aOR 2.02, 95% CI 1.160 to 3.524, p=0.013) compared with T1DM. T2DM was associated with higher inpatient mortality, septic shock and increase in healthcare utilization costs compared with T1DM.

Original languageEnglish
Pages (from-to)1196-1200
Number of pages5
JournalJournal of Investigative Medicine
Volume69
Issue number6
DOIs
StatePublished - Aug 1 2021

Fingerprint

Dive into the research topics of 'Comparing patient characteristics and outcomes in type 1 versus type 2 diabetes with diabetic ketoacidosis: A review and a propensity-matched nationwide analysis'. Together they form a unique fingerprint.

Cite this