Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma

Prashant Mahajan; Demetris Haritos; Norman Rosenberg; Ronald Thomas

doi:10.1016/j.jemermed.2004.02.006

Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma

Prashant Mahajan, Demetris Haritos, Norman Rosenberg, Ronald Thomas

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A prospective, randomized, double blinded study was conducted to determine whether a combination of nebulized magnesium sulfate and albuterol as a single dose adds any benefit in management of children with mild to moderate asthma when compared to nebulized albuterol with saline. The difference in FEV1 was significant at 10 and 20 min after a single dose of the combined treatment with magnesium and albuterol when compared with the albuterol and saline group (1.41 L ± 0.53 vs. 1.13 L ± 0.34, respectively, p = 0.03). The addition of magnesium to albuterol seems to provide short-term benefits in children with acute exacerbations of mild to moderate asthma.

Original language	English
Pages (from-to)	21-25
Number of pages	5
Journal	Journal of Emergency Medicine
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.jemermed.2004.02.006
State	Published - Jul 2004

Keywords

asthma
nebulized magnesium sulfate

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10.1016/j.jemermed.2004.02.006

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title = "Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma",

abstract = "A prospective, randomized, double blinded study was conducted to determine whether a combination of nebulized magnesium sulfate and albuterol as a single dose adds any benefit in management of children with mild to moderate asthma when compared to nebulized albuterol with saline. The difference in FEV1 was significant at 10 and 20 min after a single dose of the combined treatment with magnesium and albuterol when compared with the albuterol and saline group (1.41 L ± 0.53 vs. 1.13 L ± 0.34, respectively, p = 0.03). The addition of magnesium to albuterol seems to provide short-term benefits in children with acute exacerbations of mild to moderate asthma.",

keywords = "asthma, nebulized magnesium sulfate",

author = "Prashant Mahajan and Demetris Haritos and Norman Rosenberg and Ronald Thomas",

note = "Funding Information: This work was funded by an unrestricted grant from the Division of Pediatric Emergency Medicine, Children's Hospital of Michigan, Detroit, Michigan.",

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AU - Mahajan, Prashant

AU - Haritos, Demetris

AU - Rosenberg, Norman

AU - Thomas, Ronald

N1 - Funding Information: This work was funded by an unrestricted grant from the Division of Pediatric Emergency Medicine, Children's Hospital of Michigan, Detroit, Michigan.

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AB - A prospective, randomized, double blinded study was conducted to determine whether a combination of nebulized magnesium sulfate and albuterol as a single dose adds any benefit in management of children with mild to moderate asthma when compared to nebulized albuterol with saline. The difference in FEV1 was significant at 10 and 20 min after a single dose of the combined treatment with magnesium and albuterol when compared with the albuterol and saline group (1.41 L ± 0.53 vs. 1.13 L ± 0.34, respectively, p = 0.03). The addition of magnesium to albuterol seems to provide short-term benefits in children with acute exacerbations of mild to moderate asthma.

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Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma

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