Constitutional balanced translocations in alveolar rhabdomyosarcoma

Süreyya Savaşan, Adonis Lorenzana, James A. Williams, Anwar N. Mohamed, Yaddanapudi Ravindranath, Maria Zielenska, Merlin Hamre, Joel E. Haas, Fredrick Rector, Hadi Sawaf, Esteban Abella

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Chromosomal analysis of tumor tissue from two children with alveolar rhabdomyosarcoma revealed t(1;5)(q32;q31) and t(1;22)(q21;q11.2) in all metaphases examined, respectively. Peripheral blood lymphocytes carried the same cytogenetic abnormality as that of the tumor cells in both patients. Parental lymphocytes were karyotypically normal in the patient with t(1;22), indicating a de nova constitutional translocation, but t(1;5) was paternally inherited in the other patient. The presence of constitutional translocations in these two children might have contributed to the development of alveolar rhabdomyosarcoma.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume105
Issue number1
DOIs
StatePublished - Aug 1998

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