Continuous infusion of recombinant activated factor VII: A review of data in congenital hemophilia with inhibitors and congenital factor VII deficiency

Madhvi Rajpurkar, David L. Cooper

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Introduction: Continuous infusion (CI) of clotting factors as a replacement therapy for peri-operative hemostatic protection has been performed for many years, including with factors VIII and IX and recombinant activated factor VII (rFVIIa). This approach provides steady factor levels without requiring frequent administration of bolus doses. Aim: To review safety, efficacy, and dosing data regarding CI of rFVIIa for hemostatic management of patients with congenital hemophilia with inhibitors (CHwI) or congenital factor VII deficiency (C7D). Materials and methods: A literature review identified instances of CI of rFVIIa in patients with CHwI or C7D undergoing surgery or experiencing bleeding episodes. Data regarding safety, efficacy, and dosing were extracted. Results: The safety and efficacy of 50 mcg/kg/h CI of rFVIIa following a 90 mcg/kg bolus injection, vs a standard bolus injection regimen, was reported for 24 patients with CHwI undergoing elective surgery in an open-label, randomized, Phase III trial. Efficacy was similar between CI and bolus injection groups at all postoperative time points assessed. Additionally, a postmarket-ing surveillance study reported effective (80%) and partially effective (20%) CI of rFVIIa in a Japanese cohort of ten patients with CHwI who underwent 15 surgical procedures. Finally, the safety and dosing of rFVIIa CI in 193 and 26 patients with CHwI and C7D, respectively, were reported in 11 prospective studies, 10 retrospective studies, and 30 case reports. No unexpected safety findings were reported. Conclusion: rFVIIa CI has been performed safely and effectively in patients with CHwI and C7D undergoing surgery and during bleeding episodes in patients with CHwI.

Original languageEnglish
Pages (from-to)227-239
Number of pages13
JournalJournal of Blood Medicine
Volume9
DOIs
StatePublished - 2018

Keywords

  • Bleeding
  • Continuous infusion
  • RFVIIa
  • Surgery

Fingerprint

Dive into the research topics of 'Continuous infusion of recombinant activated factor VII: A review of data in congenital hemophilia with inhibitors and congenital factor VII deficiency'. Together they form a unique fingerprint.

Cite this