Corpus Callosotomy for Intractable Epilepsy Revisited: The Children's Hospital of Michigan Series

Aimee F. Luat, Eishi Asano, Ajay Kumar, Harry T. Chugani, Sandeep Sood

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Corpus callosotomy is a palliative procedure performed to reduce the severity of drug-resistant epilepsy. The authors assessed its efficacy on different seizure types in 20 subjects (age range 5-19 years); 8 with active vagus nerve stimulator. Fifteen had complete callosotomy, 3 had anterior 2/3, and 2 had anterior 2/3 followed later by complete callosotomy. Ten had endoscopic approach. In all, 65% had ≥ 50% reduction of generalized seizures leading to falls (atonic, tonic, myoclonic); 35% became seizure-free (follow-up period: 6 months to 9 years; mean 3 years). Seizure outcome distribution was better for generalized than for partial seizures (P =.003). Endoscopic approach was as effective as transcranial approach. Seven subjects who failed vagus nerve stimulator therapy responded with ≥50% seizure reduction. Corpus callosotomy is an effective treatment for intractable generalized epilepsy leading to falls with significant seizure reduction or even elimination of seizures, in the majority of children.

Original languageEnglish
Pages (from-to)624-629
Number of pages6
JournalJournal of Child Neurology
Volume32
Issue number7
DOIs
StatePublished - Jun 1 2017

Keywords

  • Lennox-Gastaut syndrome
  • drug-resistant epilepsy
  • endoscopic surgery
  • palliative surgery
  • pediatric epilepsy surgery

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