TY - JOUR
T1 - Corpus Callosotomy for Intractable Epilepsy Revisited
T2 - The Children's Hospital of Michigan Series
AU - Luat, Aimee F.
AU - Asano, Eishi
AU - Kumar, Ajay
AU - Chugani, Harry T.
AU - Sood, Sandeep
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NIH Grants NS064033 (EA) and RO1 NS064989 (HTC).
Publisher Copyright:
© SAGE Publications.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Corpus callosotomy is a palliative procedure performed to reduce the severity of drug-resistant epilepsy. The authors assessed its efficacy on different seizure types in 20 subjects (age range 5-19 years); 8 with active vagus nerve stimulator. Fifteen had complete callosotomy, 3 had anterior 2/3, and 2 had anterior 2/3 followed later by complete callosotomy. Ten had endoscopic approach. In all, 65% had ≥ 50% reduction of generalized seizures leading to falls (atonic, tonic, myoclonic); 35% became seizure-free (follow-up period: 6 months to 9 years; mean 3 years). Seizure outcome distribution was better for generalized than for partial seizures (P =.003). Endoscopic approach was as effective as transcranial approach. Seven subjects who failed vagus nerve stimulator therapy responded with ≥50% seizure reduction. Corpus callosotomy is an effective treatment for intractable generalized epilepsy leading to falls with significant seizure reduction or even elimination of seizures, in the majority of children.
AB - Corpus callosotomy is a palliative procedure performed to reduce the severity of drug-resistant epilepsy. The authors assessed its efficacy on different seizure types in 20 subjects (age range 5-19 years); 8 with active vagus nerve stimulator. Fifteen had complete callosotomy, 3 had anterior 2/3, and 2 had anterior 2/3 followed later by complete callosotomy. Ten had endoscopic approach. In all, 65% had ≥ 50% reduction of generalized seizures leading to falls (atonic, tonic, myoclonic); 35% became seizure-free (follow-up period: 6 months to 9 years; mean 3 years). Seizure outcome distribution was better for generalized than for partial seizures (P =.003). Endoscopic approach was as effective as transcranial approach. Seven subjects who failed vagus nerve stimulator therapy responded with ≥50% seizure reduction. Corpus callosotomy is an effective treatment for intractable generalized epilepsy leading to falls with significant seizure reduction or even elimination of seizures, in the majority of children.
KW - Lennox-Gastaut syndrome
KW - drug-resistant epilepsy
KW - endoscopic surgery
KW - palliative surgery
KW - pediatric epilepsy surgery
UR - http://www.scopus.com/inward/record.url?scp=85019720151&partnerID=8YFLogxK
U2 - 10.1177/0883073817697847
DO - 10.1177/0883073817697847
M3 - Article
C2 - 28511630
AN - SCOPUS:85019720151
VL - 32
SP - 624
EP - 629
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 7
ER -