CO2 does not affect passive exercise ventilatory decline

Harold J. Bell, James Duffin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Breathing increases abruptly at the start of passive exercise, stimulated by afferent feedback from the moving limbs, and declines toward a steady-state hyperpnea as exercise continues. This decline has been attributed to decreased arterial CO2 levels and adaptation in afferent feedback; however, the relative importance of these two mechanisms is unknown. To address this issue, we compared ventilatory responses to 5 min of passive leg extension exercise performed on 10 awake human subjects (6 men and 4 women) in isocapnic and poikilocapnic conditions. End-tidal PCO2 decreased significantly during poikilocapnic (Δ = -1.5 ± 0.5 Torr, P < 0.001), but not isocapnic, passive exercise. Despite this difference, the ventilatory responses to passive exercise were not different between the two conditions. Using the fast changes in ventilation at the start (5.46 ± 0.40 l/min, P < 0.001) and end (3.72 ± 0.33 l/min, P < 0.001) of passive exercise as measures of the drive to breathe from afferent feedback, we found a decline of 68%. We conclude that the decline in ventilation during passive exercise is due to an adaptation in the afferent feedback from the moving limbs, not a decline in CO2 levels.

Original languageEnglish
Pages (from-to)322-329
Number of pages8
JournalJournal of Applied Physiology
Volume95
Issue number1
DOIs
StatePublished - Jul 1 2003

Keywords

  • Afferent feedback
  • Breathing frequency
  • Tidal volume
  • Ventilation

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