Cytogenetic findings in two new cases of hepatoblastoma

Wassim Ali, Süreyya Savasan, Raja Rabah, Anwar N. Mohamed

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We describe two cases of hepatoblastoma occurring in an 18-month-old boy and a 3-month-old girl. Cytogenetic analysis of the primary tumors revealed gain of 2q and 20 in both cases. In case 1, t(7;8;11) was seen as a secondary abnormality. Other chromosomal aberrations seen in case 2 were unbalanced t(1;1) and t(2;11), resulting in partial gains of 1q and 2q. These results support previous reports that gains of 2q and 20 and rearrangement of chromosome 1 are strongly associated with hepatoblastoma and may be essential for establishing this neoplasm. The 11q and 7q abnormalities may represent a pathway of genetic evolution associated with hepatoblastoma progression.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume133
Issue number2
DOIs
StatePublished - 2002

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