Cytogenetic findings in two new cases of hepatoblastoma

Wassim Ali; Süreyya Savasan; Raja Rabah; Anwar N. Mohamed

doi:10.1016/S0165-4608(01)00588-X

Cytogenetic findings in two new cases of hepatoblastoma

Wassim Ali, Süreyya Savasan, Raja Rabah, Anwar N. Mohamed

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Abstract

We describe two cases of hepatoblastoma occurring in an 18-month-old boy and a 3-month-old girl. Cytogenetic analysis of the primary tumors revealed gain of 2q and 20 in both cases. In case 1, t(7;8;11) was seen as a secondary abnormality. Other chromosomal aberrations seen in case 2 were unbalanced t(1;1) and t(2;11), resulting in partial gains of 1q and 2q. These results support previous reports that gains of 2q and 20 and rearrangement of chromosome 1 are strongly associated with hepatoblastoma and may be essential for establishing this neoplasm. The 11q and 7q abnormalities may represent a pathway of genetic evolution associated with hepatoblastoma progression.

Original language	English
Pages (from-to)	179-182
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	133
Issue number	2
DOIs	https://doi.org/10.1016/S0165-4608(01)00588-X
State	Published - 2002

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title = "Cytogenetic findings in two new cases of hepatoblastoma",

abstract = "We describe two cases of hepatoblastoma occurring in an 18-month-old boy and a 3-month-old girl. Cytogenetic analysis of the primary tumors revealed gain of 2q and 20 in both cases. In case 1, t(7;8;11) was seen as a secondary abnormality. Other chromosomal aberrations seen in case 2 were unbalanced t(1;1) and t(2;11), resulting in partial gains of 1q and 2q. These results support previous reports that gains of 2q and 20 and rearrangement of chromosome 1 are strongly associated with hepatoblastoma and may be essential for establishing this neoplasm. The 11q and 7q abnormalities may represent a pathway of genetic evolution associated with hepatoblastoma progression.",

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AU - Ali, Wassim

AU - Savasan, Süreyya

AU - Rabah, Raja

AU - Mohamed, Anwar N.

PY - 2002

Y1 - 2002

N2 - We describe two cases of hepatoblastoma occurring in an 18-month-old boy and a 3-month-old girl. Cytogenetic analysis of the primary tumors revealed gain of 2q and 20 in both cases. In case 1, t(7;8;11) was seen as a secondary abnormality. Other chromosomal aberrations seen in case 2 were unbalanced t(1;1) and t(2;11), resulting in partial gains of 1q and 2q. These results support previous reports that gains of 2q and 20 and rearrangement of chromosome 1 are strongly associated with hepatoblastoma and may be essential for establishing this neoplasm. The 11q and 7q abnormalities may represent a pathway of genetic evolution associated with hepatoblastoma progression.

AB - We describe two cases of hepatoblastoma occurring in an 18-month-old boy and a 3-month-old girl. Cytogenetic analysis of the primary tumors revealed gain of 2q and 20 in both cases. In case 1, t(7;8;11) was seen as a secondary abnormality. Other chromosomal aberrations seen in case 2 were unbalanced t(1;1) and t(2;11), resulting in partial gains of 1q and 2q. These results support previous reports that gains of 2q and 20 and rearrangement of chromosome 1 are strongly associated with hepatoblastoma and may be essential for establishing this neoplasm. The 11q and 7q abnormalities may represent a pathway of genetic evolution associated with hepatoblastoma progression.

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VL - 133

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JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Cytogenetic findings in two new cases of hepatoblastoma

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