Cytokine regulation of CD40 expression in fetal human astrocyte cultures

Nahed Abdel-Haq, Hsiao Nan Hao, William D. Lyman

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

CD40 can participate in inflammatory processes after binding its cognate ligand (CD40L). We found that fetal human astrocytes constitutively express CD40 mRNA and protein. Upon incubating cultures with proinflammatory cytokines (TNF-α, IL-1β and IFN-γ) or with lipopolysaccharide (LPS), CD40 expression was increased. No change in CD40 expression was noted in astrocyte cultures incubated with IL-6, HIV or gp41. Astrocytes also showed increased release of proinflammatory cytokines TNF-α, IL-1β and IL-6 after incubation with CD40L peptide. These observations suggest a role for CD40 in central nervous system (CNS) inflammation and that CD40/CD40L autocrine or paracrine pathways may mediate this role. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalJournal of Neuroimmunology
Volume101
Issue number1
DOIs
StatePublished - Nov 1 1999

Keywords

  • Astrocytes
  • CD40
  • Central nervous system
  • Cytokines
  • Inflammation

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