Cytotoxicity of metal ions released from nitinol alloys on endothelial cells

W. Haider; N. Munroe; V. Tek; P. K.S. Gill; Y. Tang; A. J. McGoron

doi:10.1007/s11665-011-9884-5

Cytotoxicity of metal ions released from nitinol alloys on endothelial cells

W. Haider, N. Munroe, V. Tek, P. K.S. Gill, Y. Tang, A. J. McGoron

Engineering & Technology, School Of

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Most implantable medical devices are expected to function in the body over an extended period of time. Therefore, immersion tests under simulated conditions can be useful for assessing the amount of metal ions released in situ. In this investigation, dissolved ions from as-received binary and ternary Nitinol alloys in cell culture media were periodically measured under static and dynamic conditions. Endothelial cells were grown in aliquots of culture media obtained and the effect of dissolved ions on cell proliferation and viability of endothelial cells (HUVEC) was studied by cytotoxicity assays. The concentration of metal ions in the media was measured by inductively coupled plasma mass spectrometry.

Original language	English
Pages (from-to)	816-818
Number of pages	3
Journal	Journal of Materials Engineering and Performance
Volume	20
Issue number	4-5
DOIs	https://doi.org/10.1007/s11665-011-9884-5
State	Published - Jul 2011

Keywords

Biomaterials
Intermetallics
Material selection

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10.1007/s11665-011-9884-5

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abstract = "Most implantable medical devices are expected to function in the body over an extended period of time. Therefore, immersion tests under simulated conditions can be useful for assessing the amount of metal ions released in situ. In this investigation, dissolved ions from as-received binary and ternary Nitinol alloys in cell culture media were periodically measured under static and dynamic conditions. Endothelial cells were grown in aliquots of culture media obtained and the effect of dissolved ions on cell proliferation and viability of endothelial cells (HUVEC) was studied by cytotoxicity assays. The concentration of metal ions in the media was measured by inductively coupled plasma mass spectrometry.",

keywords = "Biomaterials, Intermetallics, Material selection",

author = "W. Haider and N. Munroe and V. Tek and Gill, {P. K.S.} and Y. Tang and McGoron, {A. J.}",

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AU - Haider, W.

AU - Munroe, N.

AU - Tek, V.

AU - Gill, P. K.S.

AU - Tang, Y.

AU - McGoron, A. J.

N1 - Funding Information: The project described was supported by Award Number SC3GM 084816 from the National Institute of General Medical Sciences.

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N2 - Most implantable medical devices are expected to function in the body over an extended period of time. Therefore, immersion tests under simulated conditions can be useful for assessing the amount of metal ions released in situ. In this investigation, dissolved ions from as-received binary and ternary Nitinol alloys in cell culture media were periodically measured under static and dynamic conditions. Endothelial cells were grown in aliquots of culture media obtained and the effect of dissolved ions on cell proliferation and viability of endothelial cells (HUVEC) was studied by cytotoxicity assays. The concentration of metal ions in the media was measured by inductively coupled plasma mass spectrometry.

AB - Most implantable medical devices are expected to function in the body over an extended period of time. Therefore, immersion tests under simulated conditions can be useful for assessing the amount of metal ions released in situ. In this investigation, dissolved ions from as-received binary and ternary Nitinol alloys in cell culture media were periodically measured under static and dynamic conditions. Endothelial cells were grown in aliquots of culture media obtained and the effect of dissolved ions on cell proliferation and viability of endothelial cells (HUVEC) was studied by cytotoxicity assays. The concentration of metal ions in the media was measured by inductively coupled plasma mass spectrometry.

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KW - Intermetallics

KW - Material selection

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Cytotoxicity of metal ions released from nitinol alloys on endothelial cells

Abstract

Keywords

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