Cytotoxicity of metal ions released from nitinol alloys on endothelial cells

W. Haider, N. Munroe, V. Tek, P. K.S. Gill, Y. Tang, A. J. McGoron

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Most implantable medical devices are expected to function in the body over an extended period of time. Therefore, immersion tests under simulated conditions can be useful for assessing the amount of metal ions released in situ. In this investigation, dissolved ions from as-received binary and ternary Nitinol alloys in cell culture media were periodically measured under static and dynamic conditions. Endothelial cells were grown in aliquots of culture media obtained and the effect of dissolved ions on cell proliferation and viability of endothelial cells (HUVEC) was studied by cytotoxicity assays. The concentration of metal ions in the media was measured by inductively coupled plasma mass spectrometry.

Original languageEnglish
Pages (from-to)816-818
Number of pages3
JournalJournal of Materials Engineering and Performance
Issue number4-5
StatePublished - Jul 2011


  • Biomaterials
  • Intermetallics
  • Material selection


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