TY - JOUR
T1 - Decreased nitric oxide production following extremity ischemia and reperfusion
AU - Blebea, John
AU - Bacik, Bradley
AU - Strothman, Gregory
AU - Myatt, Leslie
N1 - Funding Information:
This study was supported by research grant from the American Heart Association, Ohio Affiliate (JB).
PY - 1996/8
Y1 - 1996/8
N2 - BACKGROUND: Nitric oxide (NO), the endogenous vasodilator, is an important regulator of vascular tone. We investigated NO production following lower extremity ischemia. METHODS: Rabbits underwent 6 hours of bilateral leg ischemia followed by unrestricted reperfusion. Physiologic parameters were continuously measured and blood was assayed for NO2 and NO3. RESULTS: Acute ischemia of the lower extremities produced an immediate increase in mean arterial blood pressure while later reperfusion induced a significant decrease (P < 0.0005). There was a fall in femoral blood flow during reperfusion. NO2/NO3 concentrations decreased significantly to 89% of baseline values after ischemia and 77% after 1 hour of reperfusion (P < 0.005). A significantly higher mortality was found in association with decreased NO2/NO3 concentrations. CONCLUSIONS: Nitric oxide appears to be a regulator of regional blood flow during reperfusion following extremity ischemia. Decreased NO production may contribute to impaired regional blood flow and mortality.
AB - BACKGROUND: Nitric oxide (NO), the endogenous vasodilator, is an important regulator of vascular tone. We investigated NO production following lower extremity ischemia. METHODS: Rabbits underwent 6 hours of bilateral leg ischemia followed by unrestricted reperfusion. Physiologic parameters were continuously measured and blood was assayed for NO2 and NO3. RESULTS: Acute ischemia of the lower extremities produced an immediate increase in mean arterial blood pressure while later reperfusion induced a significant decrease (P < 0.0005). There was a fall in femoral blood flow during reperfusion. NO2/NO3 concentrations decreased significantly to 89% of baseline values after ischemia and 77% after 1 hour of reperfusion (P < 0.005). A significantly higher mortality was found in association with decreased NO2/NO3 concentrations. CONCLUSIONS: Nitric oxide appears to be a regulator of regional blood flow during reperfusion following extremity ischemia. Decreased NO production may contribute to impaired regional blood flow and mortality.
UR - http://www.scopus.com/inward/record.url?scp=0030219179&partnerID=8YFLogxK
U2 - 10.1016/S0002-9610(96)00141-9
DO - 10.1016/S0002-9610(96)00141-9
M3 - Article
C2 - 8795521
AN - SCOPUS:0030219179
VL - 172
SP - 158
EP - 162
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 2
ER -