Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: Isolation, structure determination, and biological activity as an inducer of erythropoietin

P. Cai, D. Smith, B. Katz, C. Pearce, D. Venables, D. Houck

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 μM.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number2
DOIs
StatePublished - 1998
Externally publishedYes

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