Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: Isolation, structure determination, and biological activity as an inducer of erythropoietin

P. Cai; D. Smith; B. Katz; C. Pearce; D. Venables; D. Houck

doi:10.1021/np970475c

Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: Isolation, structure determination, and biological activity as an inducer of erythropoietin

P. Cai, D. Smith, B. Katz, C. Pearce, D. Venables, D. Houck

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive ¹H and ¹³C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 μM.

Original language	English
Pages (from-to)	290-293
Number of pages	4
Journal	Journal of Natural Products
Volume	61
Issue number	2
DOIs	https://doi.org/10.1021/np970475c
State	Published - 1998
Externally published	Yes

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abstract = "In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 μM.",

author = "P. Cai and D. Smith and B. Katz and C. Pearce and D. Venables and D. Houck",

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AU - Smith, D.

AU - Katz, B.

AU - Pearce, C.

AU - Venables, D.

AU - Houck, D.

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AB - In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 μM.

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Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: Isolation, structure determination, and biological activity as an inducer of erythropoietin

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