Detection of myocardial viability based on measurement of sodium content: A 23Na-NMR study

Michael Horn, Claudia Weidensteiner, Heike Scheffer, Martin Meininger, Mark De Groot, Helga Remkes, Charlotte Dienesch, Karin Przyklenk, Markus Von Kienlin, Stefan Neubauer

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35 Scopus citations

Abstract

MRI of total sodium (Na) content may allow assessment of myocardial viability, but information on Na content in normal myocardium, necrotic/scar tissue, and stunned or hibernating myocardium is lacking. Thus, the aims of the study were to: 1) quantify the temporal changes in myocardial Na content postmyocardial infarction (MI) in a rat model (Protocol 1); 2) compare Na in normally perfused, hibernating, and stunned canine myocardium (Protocol 2); and 3) determine whether, in bufferperfused rat hearts, infarct scar can be differentiated from intact myocardium by 23Na-MRI (Protocol 3). In Protocol 1, rats were subjected to LAD ligation. Infarct/scar tissue was excised at control and 1, 3, 7, 28, 56, and 128 days post-MI (N = 6-8 each), Na content was determined by 23Na-NMR spectroscopy (MRS) and ion chromatography. Na content was persistently increased at all time points post-MI averaging 306*-160*% of control values (*P < 0.0083 vs. control). In Protocol 2, 23Na-MRS of control (baseline), stunned and hibernating samples revealed no difference in Na. In Protocol 3, 23Na-MRI revealed a mean increase in signal intensity, to 142 ± 6% of control values, in scar tissue. A threshold of 2 standard deviations of the image intensity allowed determination of infarct size, correlating with histologically determined infarct size (r = 0.91, P < 0.0001).

Original languageEnglish
Pages (from-to)756-764
Number of pages9
JournalMagnetic Resonance in Medicine
Volume45
Issue number5
DOIs
StatePublished - 2001

Keywords

  • 3D-CSI
  • Hibernating
  • Myocardial infarction
  • Ne NMR
  • Stunning
  • Viability

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