Detection of oseltamivir resistance during treatment of 2009 H1N1 influenza virus infection in immunocompromised patients: Utility of cycle threshold values of qualitative real-time reverse transcriptase PCR

Tejal Mehta, Eric McGrath, Suchitha Bheemreddy, Hossein Salimnia, Nahed Abdel-Haq, Jocelyn Y. Ang, Lawrence Lum, Pranatharthi Chandrasekar, George J. Alangaden

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Two immunocompromised patients with 2009 H1N1 influenza pneumonia had viral shedding for over 5 weeks despite therapy with oseltamivir. Declining or persistently low cycle threshold values noted on serial qualitative real-time reverse transcriptase PCR (rRT-PCR) of respiratory specimens implied increasing viral load and probable drug resistance. Oseltamivir resistance was later confirmed by pyrosequencing.

Original languageEnglish
Pages (from-to)4326-4328
Number of pages3
JournalJournal of Clinical Microbiology
Volume48
Issue number11
DOIs
StatePublished - Nov 2010

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