TY - JOUR
T1 - Detection of oseltamivir resistance during treatment of 2009 H1N1 influenza virus infection in immunocompromised patients
T2 - Utility of cycle threshold values of qualitative real-time reverse transcriptase PCR
AU - Mehta, Tejal
AU - McGrath, Eric
AU - Bheemreddy, Suchitha
AU - Salimnia, Hossein
AU - Abdel-Haq, Nahed
AU - Ang, Jocelyn Y.
AU - Lum, Lawrence
AU - Chandrasekar, Pranatharthi
AU - Alangaden, George J.
PY - 2010/11
Y1 - 2010/11
N2 - Two immunocompromised patients with 2009 H1N1 influenza pneumonia had viral shedding for over 5 weeks despite therapy with oseltamivir. Declining or persistently low cycle threshold values noted on serial qualitative real-time reverse transcriptase PCR (rRT-PCR) of respiratory specimens implied increasing viral load and probable drug resistance. Oseltamivir resistance was later confirmed by pyrosequencing.
AB - Two immunocompromised patients with 2009 H1N1 influenza pneumonia had viral shedding for over 5 weeks despite therapy with oseltamivir. Declining or persistently low cycle threshold values noted on serial qualitative real-time reverse transcriptase PCR (rRT-PCR) of respiratory specimens implied increasing viral load and probable drug resistance. Oseltamivir resistance was later confirmed by pyrosequencing.
UR - http://www.scopus.com/inward/record.url?scp=78049506507&partnerID=8YFLogxK
U2 - 10.1128/JCM.01190-10
DO - 10.1128/JCM.01190-10
M3 - Article
C2 - 20844229
AN - SCOPUS:78049506507
VL - 48
SP - 4326
EP - 4328
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 11
ER -