Development of new prognostic model based on pretreatment βLRI and LLRI for stage IE/IIE upper aerodigestive tract ENKTL, nasal type

Wumin Dai, Bo Jia, Jianliang Yang, Shengyu Zhou, Peng Liu, Xiaohui He, Yan Qin, Lin Gui, Changgong Zhang, Xiaohong Han, Yan Sun, Yuankai Shi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

To identify simple non-invasive prognostic factors for extranodal natural killer/T cell lymphoma (ENKTL), we have investigated the prognostic value of pretreatment β2-microglobin to lymphocytes ratio index (βLRI) or lactate dehydrogenase to lymphocytes ratio index (LLRI), by analyzing the retrospective data from 211 ENKTL patients. Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off value of pretreatment βLRI and LLRI. The univariate analysis indicated that Ann Arbor Stage (p = 0.008), Eastern Cooperative Oncology Group score (ECOG) (p = 0.009), International Prognostic Index (IPI) (p = 0.023), βLRI (p = 0.003), LLRI (p = 0.04), neutrophil-lymphocyte ratio index (p = 0.025) and monocyte/granulocyte to lymphocyte ratio (p = 0.030) were significantly associated with overall survival (OS) in ENKTL patients. However, multivariate analysis demonstrated that only Ann Arbor Stage (p = 0.028), βLRI (p < 0.001) and LLRI (p = 0.006) were only correlated independently with OS. Furthermore, βLRI and LLRI based new prognostic model showed improved discrimination for stage IE/IIE upper aerodigestive tract in ENKTL patients than IPI and Korean Prognostic Index. Overall, our study concluded that new βLRI-based prognosis model is useful to stratify ENKTL patients and higher βLRI and LLRI can act as independent prognostic predictor candidates in early stage ENKTL.

Original languageEnglish
Pages (from-to)34787-34795
Number of pages9
JournalOncotarget
Volume8
Issue number21
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Beta2-microglobin to lymphocytes ratio index
  • Extranodal natural killer/T cell lymphoma
  • Lactate dehydrogenase to lymphocytes ratio index
  • Prognosis
  • Systemic immune-inflammation

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