Developmental study of rat brain glutathione peroxidase and glutathione reductase

Timothy S. Brannan, Howard S. Maker, Cipora Weiss

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Glutathione peroxidase and glutathione reductase activities were measured in whole rat brains at selected ages from birth to adulthood. On a wet weight basis glutathione peroxidase activity increased 70% during development and glutathione reductase activity increased 160%. On a protein basis glutathione peroxidase declined slightly in activity during the first two weeks of life and then maintained the 14-day activity into adulthood while glutathione reductase showed a 30% increase in activity. While less than the developmental changes in many enzymes involved in aerobic glycolysis or catecholamine metabolism, these increases do suggest a role in CNS metabolism.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalNeurochemical Research
Issue number1
StatePublished - Jan 1981


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