Device-detected nonsustained ventricular tachycardia in adult congenital heart disease without tetralogy of fallot

Objectives: To evaluate any association between non-sustained ventricular tachycardia (NSVT) detected by intra-cardiac device and clinical outcomes in repaired adult congenital heart disease (ACHD) without tetralogy of Fallot (TOF). Background: NSVT portends a higher risk of serious ventricular tachyarrhythmia in TOF. However its clinical significance when incidentally detected by implantable cardiac device is not well elucidated in non-TOF ACHD cohort. Methods: We performed a single center, retrospective, longitudinal follow-up study in repaired ACHD (≥18 years) patients without TOF who hosted a pacemaker or automatic implantable cardiac defibrillator (AICD). The cohort was divided based on presence/absence of device detected NSVT. The primary end-point was a composite of sustained ventricular tachycardia (VT), ventricular fibrillation (VF), or sudden cardiac death (SCD). Results: One hundred fifty eight patients (male 56.3%, median [IQR] age of 35 [28–43] years at last follow-up] with longitudinal post-implant follow-up duration of 8 (5–12) years were included. NSVT was detected in 52 (33%) patients. The primary composite end-point was more frequent in NSVT group [11.5% vs. 2.8%; p =.04]. Patients with NSVT were (i) older at the time of initial implant (age 25 vs. 18 years, p =.011) and more frequently demonstrated (ii) systemic ventricular dysfunction (44% vs. 26%; p =.015), as well as (iii) history of ventriculotomy (38% vs. 21%; p =.017). Conclusions: In our repaired ACHD cohort, we noted a significant association between device-detected-NSVT and the primary composite end-point of sustained VT/VF or SCD. Systemic ventricular dysfunction and history of ventriculotomy were more frequent in the NSVT group and likely constituted the clinical milieu.