Diabetic ketoacidosis

Katherine Cashen, Tara Petersen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

On the basis of class D evidence and consensus, children and adolescents with diabetic ketoacidosis (DKA) should be cared for in a center experienced in the treatment of DKA. On the basis of class A evidence, goals of treatment in children with DKA are to correct dehydration, correct acidosis, and reverse ketosis. On the basis of class A evidence, fluid replacement (deficit and maintenance) should be calculated and replaced over 24 to 48 hours. On the basis of class B evidence, insulin therapy should start at a rate of 0.05 to 0.1 U/kg per hour after starting fluid replacement. On the basis of class B evidence, bicarbonate administration is not recommended except for severe hyperkalemia or severe acidosis with impaired cardiac output.

Original languageEnglish
Pages (from-to)412-420
Number of pages9
JournalPediatrics in Review
Volume40
Issue number8
DOIs
StatePublished - 2019

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