TY - JOUR
T1 - Diastolic function in anthracycline-treated children
AU - Harahsheh, Ashraf
AU - Aggarwal, Sanjeev
AU - Pettersen, Michael D.
AU - L'Ecuyer, Thomas
N1 - Publisher Copyright:
© © Cambridge University Press 2014.
PY - 2014/7/24
Y1 - 2014/7/24
N2 - Background: Anthracyclines are effective medications for childhood cancer. Their limitation is the risk of cardiomyopathy. Although diastolic dysfunction has been described in patients who received anthracyclines, cardiac monitoring has focused on systolic function, which is abnormal in up to 41% of the patients. We conducted a study to assess diastolic function utilising transmitral inflow Doppler velocities and tissue Doppler imaging in anthracycline-treated children 5 years post-therapy. Methods: This was a retrospective study on 63 anthracycline-treated patients. Echocardiographic parameters included peak early and late transmitral inflow Doppler velocities (E, A), E/A ratio, E deceleration time, and tissue Doppler imaging early and late diastolic mitral annulus velocities (E′, A′), E/E′ ratio, and E′/A′ ratio. Results: All indices of diastolic function that we measured were normal in the anthracycline-treated patients. Conclusion: We conclude that diastolic function assessed by transmitral inflow Doppler velocities and tissue Doppler imaging is normal in anthracycline-treated children 5 years after completion of treatment. Further longitudinal study is needed to determine whether diastolic function becomes abnormal with time in this patient population.
AB - Background: Anthracyclines are effective medications for childhood cancer. Their limitation is the risk of cardiomyopathy. Although diastolic dysfunction has been described in patients who received anthracyclines, cardiac monitoring has focused on systolic function, which is abnormal in up to 41% of the patients. We conducted a study to assess diastolic function utilising transmitral inflow Doppler velocities and tissue Doppler imaging in anthracycline-treated children 5 years post-therapy. Methods: This was a retrospective study on 63 anthracycline-treated patients. Echocardiographic parameters included peak early and late transmitral inflow Doppler velocities (E, A), E/A ratio, E deceleration time, and tissue Doppler imaging early and late diastolic mitral annulus velocities (E′, A′), E/E′ ratio, and E′/A′ ratio. Results: All indices of diastolic function that we measured were normal in the anthracycline-treated patients. Conclusion: We conclude that diastolic function assessed by transmitral inflow Doppler velocities and tissue Doppler imaging is normal in anthracycline-treated children 5 years after completion of treatment. Further longitudinal study is needed to determine whether diastolic function becomes abnormal with time in this patient population.
KW - Cardiomyopathy
KW - echocardiogram
KW - paediatric cardiology
KW - tissue Doppler imaging
UR - http://www.scopus.com/inward/record.url?scp=84945440586&partnerID=8YFLogxK
U2 - 10.1017/S1047951114001760
DO - 10.1017/S1047951114001760
M3 - Article
C2 - 25247608
AN - SCOPUS:84945440586
VL - 25
SP - 1130
EP - 1135
JO - Cardiology in the Young
JF - Cardiology in the Young
SN - 1047-9511
IS - 6
ER -