Diastolic function in anthracycline-treated children

Ashraf Harahsheh, Sanjeev Aggarwal, Michael D. Pettersen, Thomas L'Ecuyer

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Anthracyclines are effective medications for childhood cancer. Their limitation is the risk of cardiomyopathy. Although diastolic dysfunction has been described in patients who received anthracyclines, cardiac monitoring has focused on systolic function, which is abnormal in up to 41% of the patients. We conducted a study to assess diastolic function utilising transmitral inflow Doppler velocities and tissue Doppler imaging in anthracycline-treated children 5 years post-therapy. Methods: This was a retrospective study on 63 anthracycline-treated patients. Echocardiographic parameters included peak early and late transmitral inflow Doppler velocities (E, A), E/A ratio, E deceleration time, and tissue Doppler imaging early and late diastolic mitral annulus velocities (E′, A′), E/E′ ratio, and E′/A′ ratio. Results: All indices of diastolic function that we measured were normal in the anthracycline-treated patients. Conclusion: We conclude that diastolic function assessed by transmitral inflow Doppler velocities and tissue Doppler imaging is normal in anthracycline-treated children 5 years after completion of treatment. Further longitudinal study is needed to determine whether diastolic function becomes abnormal with time in this patient population.

Original languageEnglish
Pages (from-to)1130-1135
Number of pages6
JournalCardiology in the Young
Issue number6
StatePublished - Jul 24 2014


  • Cardiomyopathy
  • echocardiogram
  • paediatric cardiology
  • tissue Doppler imaging


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