TY - JOUR
T1 - Dietary supplementation with omega-3 fatty acids and oleate enhances exercise training effects in patients with metabolic syndrome
AU - Ortega, Juan F.
AU - Morales-Palomo, Felix
AU - Fernandez-Elias, Valentin
AU - Hamouti, Nassim
AU - Bernardo, Francisco J.
AU - Martin-Doimeadios, Rosa C.
AU - Nelson, Rachael K.
AU - Horowitz, Jeffrey F.
AU - Mora-Rodriguez, Ricardo
N1 - Publisher Copyright:
© 2016 The Obesity Society
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objective: We studied the effects of exercise training alone or combined with dietary supplementation of omega-3 polyunsaturated fatty acids (Ω-3PUFA) and oleate on metabolic syndrome (MSyn) components and other markers of cardiometabolic health. Methods: Thirty-six patients with MSyn underwent 24 weeks of high-intensity interval training. In a double-blind randomized design, half of the group ingested 500 mL/day of semi-skim milk (8 g of fat; placebo milk) whereas the other half ingested 500 mL/day of skim milk enriched with 275 mg of Ω-3PUFA and 7.5 g of oleate (Ω-3 + OLE). Results: Ω-3 + OLE treatment elevated 30% plasma Ω-3PUFA but not significantly (P = 0.286). Improvements in VO2peak (12.8%), mean blood pressure (−7.1%), waist circumference (−1.8%), body fat mass (−2.9%), and trunk fat mass (−3.3%) were similar between groups. However, insulin sensitivity (measured by intravenous glucose tolerance test), serum concentration of C-reactive protein, and high-density lipoprotein improved only in the Ω-3 + OLE group by 31.5%, 32.1%, and 10.3%, respectively (all P < 0.05). Fasting serum triacylglycerol, glucose, and plasma fibrinogen concentrations did not improve in either group after 24 weeks of intervention. Conclusions: Diet supplementation with Ω-3PUFA and oleate enhanced cardiometabolic benefits of intense aerobic exercise training in patients with MSyn.
AB - Objective: We studied the effects of exercise training alone or combined with dietary supplementation of omega-3 polyunsaturated fatty acids (Ω-3PUFA) and oleate on metabolic syndrome (MSyn) components and other markers of cardiometabolic health. Methods: Thirty-six patients with MSyn underwent 24 weeks of high-intensity interval training. In a double-blind randomized design, half of the group ingested 500 mL/day of semi-skim milk (8 g of fat; placebo milk) whereas the other half ingested 500 mL/day of skim milk enriched with 275 mg of Ω-3PUFA and 7.5 g of oleate (Ω-3 + OLE). Results: Ω-3 + OLE treatment elevated 30% plasma Ω-3PUFA but not significantly (P = 0.286). Improvements in VO2peak (12.8%), mean blood pressure (−7.1%), waist circumference (−1.8%), body fat mass (−2.9%), and trunk fat mass (−3.3%) were similar between groups. However, insulin sensitivity (measured by intravenous glucose tolerance test), serum concentration of C-reactive protein, and high-density lipoprotein improved only in the Ω-3 + OLE group by 31.5%, 32.1%, and 10.3%, respectively (all P < 0.05). Fasting serum triacylglycerol, glucose, and plasma fibrinogen concentrations did not improve in either group after 24 weeks of intervention. Conclusions: Diet supplementation with Ω-3PUFA and oleate enhanced cardiometabolic benefits of intense aerobic exercise training in patients with MSyn.
UR - http://www.scopus.com/inward/record.url?scp=84979651411&partnerID=8YFLogxK
U2 - 10.1002/oby.21552
DO - 10.1002/oby.21552
M3 - Article
C2 - 27356240
AN - SCOPUS:84979651411
VL - 24
SP - 1704
EP - 1711
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 8
ER -