TY - JOUR
T1 - Differential effects of reperfusion on incidence of ventricular arrhythmias and recovery of ventricular function at 4 days following coronary occlusion
AU - Arnold, J. Malcolm O.
AU - Antman, Elliott M.
AU - Przyklenk, Karin
AU - Braunwald, Eugene
AU - Sandor, Tamas
AU - Vivaldi, Maria T.
AU - Schoen, Frederick J.
AU - Kloner, Robert A.
N1 - Funding Information:
From the Departments of Medicine, Radiology,* and Pathology,** vard Medical School, Brigham and Women’s Hospital. Supported in part by Grants HL-23140, HL-28048, and SC!OR HL-26215 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. Dr. Arnold was a British-American Fellow of the British Heart Foundation and the American Heart Association. Dr. Przyklenk holds a post-doctoral fellowship from the Medical Research Council of Canada. This work was done during the tenure of an Established Investigatorship from the American Heart Association (Dr. Kloner) with funds contributed in part by the Massachusetts Heart Association. for publication 22, 1986; accepted Oct. 3, 1986. requests: Elliott Antman, M.D., Cardiovascular Division, and Women’s 75 Francis St., Boston, M-4 02115.
PY - 1987/5
Y1 - 1987/5
N2 - To determine the influence of coronary reperfusion on ventricular arrhythmias and ventricular function at 4 days post occlusion, anesthetized dogs randomly received no occlusion (sham, permanent occlusion, or 1-, 2-, 3-, 4-, or 6-hour occlusions of the left anterior descending coronary artery, followed by reperfusion. An ambulatory ECG was recorded between 78 and 96 hours. The total runs of ventricular tachycardia were 1 ± 0 (sham), 155 ± 001 (1 hour), 66 ± 32 (2 hours), 56 ± 35 (3 hours), 167 ± 68 (4 hours), 942 ± 618 (6 hours), and 1422 ± 486 (permanent occlusion); the runs of ventricular tachycardia were significantly less in the combined 1- to 4-hour groups (93 ± 24) compared to the 6-hour and permanent occlusion groups (1282 ± 384; p < 0.006). Similar results were obtained for the number of hours in which ventricular tachycardia or frequent ventricular premature beats occurred. At 96 hours, improvement in percent systolic wall thickening of the ischemic myocardium assessed by two-dimensional echocardiography was seen in the group reperfused at 1 hour (p < 0.01). Similar results were obtained for the reduction in degrees of wall circumference showing systolic thinning. In summary, at 4 days post occlusion in a dog model, spontaneous ventricular arrhythmias are reduced by reperfusion within 4 hours, while return of ventricular function is only improved by reperfusion within approximately 1 hour of coronary occlusion.
AB - To determine the influence of coronary reperfusion on ventricular arrhythmias and ventricular function at 4 days post occlusion, anesthetized dogs randomly received no occlusion (sham, permanent occlusion, or 1-, 2-, 3-, 4-, or 6-hour occlusions of the left anterior descending coronary artery, followed by reperfusion. An ambulatory ECG was recorded between 78 and 96 hours. The total runs of ventricular tachycardia were 1 ± 0 (sham), 155 ± 001 (1 hour), 66 ± 32 (2 hours), 56 ± 35 (3 hours), 167 ± 68 (4 hours), 942 ± 618 (6 hours), and 1422 ± 486 (permanent occlusion); the runs of ventricular tachycardia were significantly less in the combined 1- to 4-hour groups (93 ± 24) compared to the 6-hour and permanent occlusion groups (1282 ± 384; p < 0.006). Similar results were obtained for the number of hours in which ventricular tachycardia or frequent ventricular premature beats occurred. At 96 hours, improvement in percent systolic wall thickening of the ischemic myocardium assessed by two-dimensional echocardiography was seen in the group reperfused at 1 hour (p < 0.01). Similar results were obtained for the reduction in degrees of wall circumference showing systolic thinning. In summary, at 4 days post occlusion in a dog model, spontaneous ventricular arrhythmias are reduced by reperfusion within 4 hours, while return of ventricular function is only improved by reperfusion within approximately 1 hour of coronary occlusion.
UR - http://www.scopus.com/inward/record.url?scp=0023275110&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(87)90912-4
DO - 10.1016/0002-8703(87)90912-4
M3 - Article
C2 - 3577998
AN - SCOPUS:0023275110
VL - 113
SP - 1055
EP - 1065
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 5
ER -