Dimercaptosuccinic acid (DMSA) renal scan in the evaluation of hypertension in children

Maheen Ahmed, Daniel Eggleston, Gaurav Kapur, Amrish Jain, Rudolph P. Valentini, Tej K. Mattoo

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Renal scarring is known to be associated with hypertension. The primary objective of this study was to investigate the prevalence of renal scarring in children referred to our clinic with hypertension. The secondary objective was to compare renal ultrasound (US) examination with dimercaptosuccinic acid (DMSA) renal scan in diagnosing renal scars in these patients. The study included 159 patients who underwent DMSA renal scan as well as renal US for the evaluation of hypertension of unknown etiology. Thirty-three (21%) patients were found to have renal scars; their demographic details, including mean age and gender distribution, were not significantly different from those without renal scars. In comparison with the DMSA renal scan, sensitivity and specificity of renal US in diagnosing renal scars were 36% and 94%, respectively. In our study, in which the prevalence of scarring was 21%, this gave positive predictive and negative predictive values of 63% and 85%, respectively. In conclusion, our study indicates that renal scarring is present in 21% of otherwise healthy children who are evaluated for newly diagnosed hypertension, and renal US is not a sensitive imaging modality to rule out renal scarring.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalPediatric Nephrology
Issue number3
StatePublished - Mar 2008


  • Children
  • DMSA scan
  • Hypertension
  • Renal scarring
  • Ultrasonography


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