Early oxygenation and ventilation measurements after pediatric cardiac arrest: Lack of association with outcome

Kimberly Statler Bennett, Amy E. Clark, Kathleen L. Meert, Alexis A. Topjian, Charles L. Schleien, Donald H. Shaffner, J. Michael Dean, Frank W. Moler

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


OBJECTIVES: To explore oxygenation and ventilation status early after cardiac arrest in infants and children. We hypothesize that hyperoxia is common and associated with worse outcome after pediatric cardiac arrest. DESIGN: Retrospective cohort study. SETTING: Fifteen hospitals within the Pediatric Emergency Care Applied Research Network. PATIENTS: Children who suffered a cardiac arrest event and survived for at least 6 hours after return of circulation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Analysis of 195 events revealed that abnormalities in oxygenation and ventilation are common during the initial 6 hours after pediatric cardiac arrest. Hyperoxia was frequent, affecting 54% of patients. Normoxia was documented in 34% and hypoxia in 22% of patients. These percentages account for a 10% overlap of patients who had both hyperoxia and hypoxia. Ventilation status was more evenly distributed with hyperventilation observed in 38%, normoventilation in 29%, and hypoventilation in 46%, with a 13% overlap of patients who had both hyperventilation and hypoventilation. Derangements in both oxygenation and ventilation were common early after cardiac arrest such that both normoxia and normocarbia were documented in only 25 patients (13%). Neither oxygenation nor ventilation status was associated with outcome. After controlling for potential confounders, arrest location and rhythm were significantly associated with worse outcome; however, hyperoxia was not (odds ratio for good outcome, 1.02 [0.46, 2.84]; p = 0.96). CONCLUSIONS: Despite recent resuscitation guidelines that advocate maintenance of normoxia and normoventilation after pediatric cardiac arrest, this is uncommonly achieved in practice. Although we did not demonstrate an association between hyperoxia and worse outcome, the small proportion of patients kept within normal ranges limited our power. Preclinical data suggesting potential harm with hyperoxia remain compelling, and further investigation, including prospective, large studies involving robust recording of physiological derangements, is necessary to further advance our understanding of this important topic.

Original languageEnglish
Pages (from-to)1534-1542
Number of pages9
JournalCritical Care Medicine
Issue number6
StatePublished - Jun 2013


  • hypercarbia
  • hyperoxia
  • hyperventilation
  • hypocarbia
  • hypoxia
  • resuscitation


Dive into the research topics of 'Early oxygenation and ventilation measurements after pediatric cardiac arrest: Lack of association with outcome'. Together they form a unique fingerprint.

Cite this