Effect of an exclusive human milk diet on feeding tolerance in preterm infants

Hiba El-Fadeel, Pradeep Velumula, Mirjana Lulic-Botica, Girija Natarajan, Ronald Thomas, Gabriella Botica, Monika Bajaj

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective: To compare the time to full enteral feeds in preterm infants fed exclusive human milk (EHM) - mother’s own milk (MOM) fortified with human milk-based fortifier (HMBF), to those who received partial human milk (PHM) - MOM fortified with bovine milk-based fortifier (BMBF), and exclusive formula. Study design: A single-center retrospective study of infants with birth weight <1250 g from 2013 to 2018. Data on feeding, growth and other short-term neonatal morbidities were collected. Results: On regression analysis, time to full enteral feeds was significantly higher in PHM compared to EHM group (β-coefficient 4.14, 95% CI 0.00–8.29) and formula-fed group compared to EHM (β-coefficient 4.3, 95% CI 0.32–8.20). No significant differences in growth velocity, length of stay and other morbidities were found between the groups. Conclusion: Infants in EHM had better feeding tolerance and reached their enteral feed goals sooner compared to PHM and formula-fed groups.

Original languageEnglish
Pages (from-to)1070-1075
Number of pages6
JournalJournal of Perinatology
Issue number8
StatePublished - Aug 2022


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