Effect of beta-blockers on the heart rhythm complexity in children

Ahmet Ugur, Selman Nas, Volkan Tuzcu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Beta-blockers are often used in the treatment of various heart diseases and affect the heart rate variability. In this study we aimed to assess the effect of various types of beta-blockers on the heart rate complexity in children using the multiscale entropy and detrended fluctuation analysis (DFA). The study involved 21 patients who were treated with beta-blockers for supraventricular tachycardia and 15 healthy children with normal cardiac assessments. The heart rate data was extracted from 24-hour Holter recordings and the DFA and multiscale entropy analyses were performed. The entropy was significantly higher in children who were treated with beta-blockers (MANOVA, p < 0.001). However DFA did not reveal significant difference between the two groups. Higher entropy indicates an increase in the heart rate complexity. Entropy and fractal behavior can change critically in disease states and the effect of beta-blockers can potentially be very useful in predicting clinical outcome.

Original languageEnglish
Title of host publication2011 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2011 - Conference Digest
Pages1123-1127
Number of pages5
DOIs
StatePublished - 2011
Event2011 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2011 - Anchorage, AK, United States
Duration: Oct 9 2011Oct 12 2011

Publication series

NameConference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
ISSN (Print)1062-922X

Conference

Conference2011 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2011
Country/TerritoryUnited States
CityAnchorage, AK
Period10/9/1110/12/11

Keywords

  • beta-blockers
  • fractal analysis
  • heart rate variability
  • multiscale entropy

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