TY - JOUR
T1 - Effects of depth electrode montage and single-pulse electrical stimulation sites on neuronal responses and effective connectivity
AU - Mitsuhashi, Takumi
AU - Sonoda, Masaki
AU - Iwaki, Hirotaka
AU - Luat, Aimee F.
AU - Sood, Sandeep
AU - Asano, Eishi
N1 - Funding Information:
We are grateful to Karin Halsey, BS, REEGT and Jamie MacDougall, RN, BSN, CPN at Children's Hospital of Michigan for the collaboration and assistance in performing the studies described above. This work was supported by NIH grant NS064033 (to E.A.) and JST CREST grant JPMJCR1784 (to T.M.).
Funding Information:
We are grateful to Karin Halsey, BS, REEGT and Jamie MacDougall, RN, BSN, CPN at Children's Hospital of Michigan for the collaboration and assistance in performing the studies described above. This work was supported by NIH grant NS064033 (to E.A.) and JST CREST grant JPMJCR1784 (to T.M.).
Publisher Copyright:
© 2020 International Federation of Clinical Neurophysiology
PY - 2020/12
Y1 - 2020/12
N2 - Objective: To determine the optimal depth electrode montages for the assessment of effective connectivity based on single-pulse electrical stimulation (SPES). To determine the effect of SPES locations on the extent of resulting neuronal propagations. Methods: We studied 14 epilepsy patients who underwent invasive monitoring with depth electrodes and measurement of cortico-cortical evoked potentials (CCEPs) and cortico-cortical spectral responses (CCSRs). We determined the effects of electrode montage and stimulus sites on the CCEP/CCSR amplitudes. Results: Bipolar and Laplacian montages effectively reduced the degree of SPES-related signal deflections at extra-cortical levels, including outside the brain, while maintaining those at the cortical level. SPES of structures more proximal to the deep white matter, compared to the cortical surface, elicited greater CCEPs and CCSRs. Conclusions: On depth electrode recording, bipolar and Laplacian montages are suitable for measurement of near-field CCEPs and CCSRs. SPES of the white matter axons may induce neuronal propagations to extensive regions of the cerebral cortex. Significance: This study helps to establish the practical guidelines on the diagnostic use of CCEPs/CCSRs.
AB - Objective: To determine the optimal depth electrode montages for the assessment of effective connectivity based on single-pulse electrical stimulation (SPES). To determine the effect of SPES locations on the extent of resulting neuronal propagations. Methods: We studied 14 epilepsy patients who underwent invasive monitoring with depth electrodes and measurement of cortico-cortical evoked potentials (CCEPs) and cortico-cortical spectral responses (CCSRs). We determined the effects of electrode montage and stimulus sites on the CCEP/CCSR amplitudes. Results: Bipolar and Laplacian montages effectively reduced the degree of SPES-related signal deflections at extra-cortical levels, including outside the brain, while maintaining those at the cortical level. SPES of structures more proximal to the deep white matter, compared to the cortical surface, elicited greater CCEPs and CCSRs. Conclusions: On depth electrode recording, bipolar and Laplacian montages are suitable for measurement of near-field CCEPs and CCSRs. SPES of the white matter axons may induce neuronal propagations to extensive regions of the cerebral cortex. Significance: This study helps to establish the practical guidelines on the diagnostic use of CCEPs/CCSRs.
KW - Effective connectivity
KW - Electrocorticography (ECoG)
KW - Functional brain mapping
KW - Intracranial recording
KW - Pediatric epilepsy surgery
KW - Stereo-electroencephalography (sEEG)
KW - Video EEG monitoring
UR - http://www.scopus.com/inward/record.url?scp=85094555960&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2020.09.010
DO - 10.1016/j.clinph.2020.09.010
M3 - Article
C2 - 33130438
AN - SCOPUS:85094555960
VL - 131
SP - 2781
EP - 2792
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 12
ER -