Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools

Matthew D. Lynx; Darcy D. Laclair; Edward E. McKee

doi:10.1128/AAC.01115-08

Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools

Matthew D. Lynx, Darcy D. Laclair, Edward E. McKee

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

To test whether zidovudine (3′-azido-3′-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynucleotide levels. These results suggest that AZT toxicity may not be related to deoxynucleotide pool alterations.

Original language	English
Pages (from-to)	1252-1255
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	53
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01115-08
State	Published - Mar 2009

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abstract = "To test whether zidovudine (3′-azido-3′-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynucleotide levels. These results suggest that AZT toxicity may not be related to deoxynucleotide pool alterations.",

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AU - Laclair, Darcy D.

AU - McKee, Edward E.

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AB - To test whether zidovudine (3′-azido-3′-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynucleotide levels. These results suggest that AZT toxicity may not be related to deoxynucleotide pool alterations.

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ER -

Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools

Abstract

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