[Efficacy and safety of Erlotinib in the treatment for advanced non-small cell lung cancer in Chinese patients].

Yi long Wu, Mei lin Liao, Shu kui Qin, Yan Sun, Cai cun Zhou

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

To observe the efficacy and the adverse effects of erlotinib in the treatment for advanced non-small cell lung cancer (NSCLC) in Chinese patients. From November 2005 to March 2009, a total of 519 patients with unresectable, local advanced, relapsed or metastatic NSCLC were enrolled in the trial. All the patients were treated with erlotinib 150 mg/day until disease progression or intolerable toxicity or for other reasons. The response rate, time to disease progression, overall survival and toxicity were analyzed. Of these 519 patients, 1 case had complete response, 127 cases had partial response and 263 cases had stable disease, resulting in an overall response rate (CR + PR) of 26.7%, disease stable rate of 54.9% and disease control rate (CR + PR + SD) of 81.6%. The median time to progression was 6.44 months and median overall survival was 15.37 months. The major erlotinib treatment-related adverse events (AE) were mild (CTC AE 1/2), only 3 cases had severe adverse effect, 1 case had interstitial lung disease and died of respiratory failure. The study presents excellent response rates, time to progression and overall survival of erlotinib treatment for advanced NSCLC in Chinese patients, and its adverse events are tolerable.

Original languageEnglish
Pages (from-to)148-151
Number of pages4
JournalZhonghua zhong liu za zhi [Chinese journal of oncology]
Volume32
Issue number2
StatePublished - Feb 2010

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