Electrochemical & osteoblast adhesion study of engineered TiO2 nanotubular surfaces on titanium alloys

Zia Ur Rahman, Waseem Haider, Luis Pompa, K. M. Deen

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


TiO2 nanotubes were grafted on the surface of cpTi, Ti6Al4V and Ti6Al4V-ELI with the aim to provide a new podium for human pre-osteoblast cell (MC3T3) adhesion and proliferation. The surface morphology and chemistry of these alloys were examined with scanning electron microscopy and energy dispersive x-ray spectroscopy. TiO2 nanotubes were further characterized by cyclic potentiodynamic polarization tests and electrochemical impedance spectroscopy. The vertically aligned nanotubes were subjected to pre-osteoblast cell proliferation in order to better understand cell-material interaction. The study demonstrated that these cells interact differently with nanotubes of different titanium alloys. The significant acceleration in the growth rate of pre-osteoblast cell adhesion and proliferation is also witnessed. Additionally, the cytotoxicity of the leached metal ions was evaluated by using a tetrazolium-based bio-assay, MTS. Each group of data was operated for p < 0.05, concluded one way ANOVA to investigate the significance difference.

Original languageEnglish
Pages (from-to)160-168
Number of pages9
JournalMaterials Science and Engineering C
StatePublished - Jan 1 2016


  • Electrochemical
  • Impedance spectroscopy
  • Nanotubes
  • Osteoblast
  • Potentiodynamic


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