Abstract
We report the first study on the electronic effects of ortho-substituents in dendritic antioxidants. Six antioxidants were designed to contain a common phenol ring to provide a baseline antioxidant activity, attached to two other phenol rings with H atoms (reference compound), electron donating groups (EDGs), or electron withdrawing groups (EWGs) ortho to the phenolic OH. These antioxidants were synthesized via reductive amination. Based on the DPPH assay, EDGs (o-OCH3) strongly enhanced while EWGs (o-NO2) significantly decreased the antioxidant activity. The halogens (o-Cl and o-Br) did not show any significant effect.
Original language | English |
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Article number | 151607 |
Journal | Tetrahedron Letters |
Volume | 61 |
Issue number | 11 |
DOIs | |
State | Published - Mar 12 2020 |
Keywords
- Antioxidant
- DPPH
- Dendrimer
- Electronic effect