Emerging roles of angiopoietin-like proteins in inflammation: Mechanisms and potential as pharmacological targets

Jing Yang, Qiu yi Song, Shu xuan Niu, Hui jing Chen, Robert B. Petersen, Yu Zhang, Kun Huang

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Angiopoietin-like proteins (ANGPTLs), a family of eight secreted glycoproteins termed ANGTPL1-8, are involved in angiogenesis, lipid metabolism, cancer progression, and inflammation. Their roles in regulating lipid metabolism have been intensively studied, as some ANGPTLs are promising pharmacological targets for hypertriglyceridemia and associated cardiovascular disease. Recently, the emerging roles of ANGPTLs in inflammation have attracted great attention. First, elevated levels of multiple circulating ANGPTLs in inflammatory diseases make them potential disease biomarkers. Second, multiple ANGPTLs regulate acute or chronic inflammation via various mechanisms, including triggering inflammatory signaling through their action as ligands for integrin or forming homo- /hetero-oligomers to regulate signal transduction via extra- or intracellular mechanisms. As dysregulation of the inflammatory response is a critical trigger in many diseases, understanding the roles of ANGPTLs in inflammation will aid in drug/therapy development. Here, we summarize the roles, mechanisms, and potential therapeutic values for ANGPTLs in inflammation and inflammatory diseases.

Original languageEnglish
Pages (from-to)98-117
Number of pages20
JournalJournal of Cellular Physiology
Volume237
Issue number1
DOIs
StatePublished - Jan 2022

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