Enhanced Identification of Group B Streptococcus and Escherichia coli in Young Infants with Meningitis Using the Biofire Filmarray Meningitis/Encephalitis Panel

Harbir Singh Arora, Basim I. Asmar, Hossein Salimnia, Prashant Agarwal, Sanjay Chawla, Nahed Abdel-Haq

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

FilmArray Meningitis/Encephalitis (ME) polymerase chain reaction (PCR) panel was tested on 62 cerebrospinal fluid (CSF) samples from young infants (0-3 months) with suspected meningitis and compared with CSF cultures. Twelve CSF samples from 9 infants were positive by ME PCR panel (10 Group B Streptococcus (GBS) and 2 Escherichia coli) of which only 5 were positive by culture. The 7 CSF samples that were positive only by ME PCR panel were obtained from infants who had received prior antibiotic treatment. The ME PCR panel can be a useful tool in the rapid diagnosis of bacterial meningitis in pretreated young infants.

Original languageEnglish
Pages (from-to)685-687
Number of pages3
JournalPediatric Infectious Disease Journal
Volume36
Issue number7
DOIs
StatePublished - Jul 1 2017

Keywords

  • CSF PCR
  • E. coli meningitis
  • GBS meningitis
  • meningitis in young infants
  • neonatal meningitis

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