TY - JOUR
T1 - Epidemiology of Invasive Fungal Infections at Two Tertiary Care Neonatal Intensive Care Units Over a 12-Year Period (2000-2011)
AU - Agarwal, Roshani R.
AU - Agarwal, Rajkumar L.
AU - Chen, Xinguang
AU - Lua, Jorge L.
AU - Ang, Jocelyn Y.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from Astellas Scientific and Medical Affairs, Inc.
Publisher Copyright:
© The Author(s) 2017.
PY - 2017
Y1 - 2017
N2 - We conducted a retrospective review of 168 patients with invasive fungal infections from January 2000 to December 2011 in 2 neonatal intensive care units. Patients with Candida bloodstream infection (BSI, n = 152) were further analyzed. C albicans was the most common species overall (47%); however, there was an increase in non–albicans sp from 2006 to 2011. Candida BSI clearance rates were lower in extremely low birth weight infants (77% vs 93%, P =.01) and in patients with C albicans infections (77% vs 91%, P =.01). Clearance rates improved from 2000 to 2005 (70% - 90%) to 2006 to 2011 (86% -100%). Combination antifungal use increased during the later years (73% vs 49%, P <.05) and in patients with end-organ dissemination (83% vs 54%, P <.05). We concluded that extremely low birth weight infants and C albicans infection are factors associated with nonclearance of Candida BSI. Successful clearance of Candida BSI improved in 2006 to 2011, perhaps due to increase in non–albicans species and the use of combination antifungals.
AB - We conducted a retrospective review of 168 patients with invasive fungal infections from January 2000 to December 2011 in 2 neonatal intensive care units. Patients with Candida bloodstream infection (BSI, n = 152) were further analyzed. C albicans was the most common species overall (47%); however, there was an increase in non–albicans sp from 2006 to 2011. Candida BSI clearance rates were lower in extremely low birth weight infants (77% vs 93%, P =.01) and in patients with C albicans infections (77% vs 91%, P =.01). Clearance rates improved from 2000 to 2005 (70% - 90%) to 2006 to 2011 (86% -100%). Combination antifungal use increased during the later years (73% vs 49%, P <.05) and in patients with end-organ dissemination (83% vs 54%, P <.05). We concluded that extremely low birth weight infants and C albicans infection are factors associated with nonclearance of Candida BSI. Successful clearance of Candida BSI improved in 2006 to 2011, perhaps due to increase in non–albicans species and the use of combination antifungals.
KW - Candida
KW - NICU
KW - clearance
KW - dissemination
KW - invasive fungal infections
UR - http://www.scopus.com/inward/record.url?scp=85041234272&partnerID=8YFLogxK
U2 - 10.1177/2333794X17696684
DO - 10.1177/2333794X17696684
M3 - Article
AN - SCOPUS:85041234272
VL - 4
JO - Global Pediatric Health
JF - Global Pediatric Health
SN - 2333-794X
ER -