Epolones: Novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells

Ping Cai; David Smith; Bernadette Cunningham; Sheryl Brown-Shimer; Barry Katz; Cedric Pearce; Debra Venables; David Houck

doi:10.1021/np9800506

Epolones: Novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells

Ping Cai, David Smith, Bernadette Cunningham, Sheryl Brown-Shimer, Barry Katz, Cedric Pearce, Debra Venables, David Houck

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive ¹H and ¹³C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 μM.

Original language	English
Pages (from-to)	791-795
Number of pages	5
Journal	Journal of Natural Products
Volume	61
Issue number	6
DOIs	https://doi.org/10.1021/np9800506
State	Published - Jun 1998
Externally published	Yes

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title = "Epolones: Novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells",

abstract = "In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 μM.",

author = "Ping Cai and David Smith and Bernadette Cunningham and Sheryl Brown-Shimer and Barry Katz and Cedric Pearce and Debra Venables and David Houck",

year = "1998",

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T2 - Novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells

AU - Cai, Ping

AU - Smith, David

AU - Cunningham, Bernadette

AU - Brown-Shimer, Sheryl

AU - Katz, Barry

AU - Pearce, Cedric

AU - Venables, Debra

AU - Houck, David

PY - 1998/6

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N2 - In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 μM.

AB - In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 μM.

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Epolones: Novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells

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