Epolones: Novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells

Ping Cai, David Smith, Bernadette Cunningham, Sheryl Brown-Shimer, Barry Katz, Cedric Pearce, Debra Venables, David Houck

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 μM.

Original languageEnglish
Pages (from-to)791-795
Number of pages5
JournalJournal of Natural Products
Volume61
Issue number6
DOIs
StatePublished - Jun 1998
Externally publishedYes

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