TY - JOUR
T1 - Epstein-Barr Virus Versus Novel Coronavirus-Induced Hemophagocytic Lymphohistocytosis
T2 - The Uncharted Waters
AU - Amir, Rawan
AU - Kichloo, Asim
AU - Singh, Jagmeet
AU - Bhanot, Ravinder
AU - Aljadah, Michael
AU - Kumar, Akshay
AU - Albosta, Michael Stanley
AU - Solanki, Shantanu
N1 - Publisher Copyright:
© 2020 American Federation for Medical Research.
PY - 2020
Y1 - 2020
N2 - Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, and pancytopenia. It may be associated with genetic mutations or viral/bacterial infections, most commonly Epstein-Barr virus (EBV) and cytomegalovirus. As for the novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as COVID-19 (coronavirus disease-2019), the cytokine storm it triggers can theoretically lead to syndromes similar to HLH. In this article, we report a case of a 28-year-old female who presented with high-grade fevers, found to have both SARS-CoV-2 and EBV infections, and eventually began to show signs of early HLH. To our knowledge, this is the first case reported in literature that raises the possibility of SARS-CoV-2–related HLH development.
AB - Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, and pancytopenia. It may be associated with genetic mutations or viral/bacterial infections, most commonly Epstein-Barr virus (EBV) and cytomegalovirus. As for the novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as COVID-19 (coronavirus disease-2019), the cytokine storm it triggers can theoretically lead to syndromes similar to HLH. In this article, we report a case of a 28-year-old female who presented with high-grade fevers, found to have both SARS-CoV-2 and EBV infections, and eventually began to show signs of early HLH. To our knowledge, this is the first case reported in literature that raises the possibility of SARS-CoV-2–related HLH development.
KW - COVID-19
KW - EBV
KW - hemophagocytic lymphohistocytosis
UR - http://www.scopus.com/inward/record.url?scp=85089410606&partnerID=8YFLogxK
U2 - 10.1177/2324709620950107
DO - 10.1177/2324709620950107
M3 - Article
C2 - 32787459
AN - SCOPUS:85089410606
SN - 2324-7096
VL - 8
JO - Journal of Investigative Medicine High Impact Case Reports
JF - Journal of Investigative Medicine High Impact Case Reports
ER -