Establishment of a diazepam preference in human volunteers following a differential-conditioning history of placebo versus diazepam choice

Sheila M. Alessi, John M. Roll, Mark P. Reilly, Chris Ellyn Johanson

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

This study examined whether preference for a drug (diazepam or placebo) could be switched using conditioning procedures. During the first 4 sessions of Phase 1, 6 participants received 5 mg of diazepam or placebo under double-blind conditions. During the remaining 5 sessions of Phase 1, participants selected the drug they wished to receive. The first 4 sessions of Phase 2 were a replication of Phase 1, except that following ingestion of the drug, participants completed a computer task for which they could earn money. Payment for the computer task was lowest following ingestion of the drug they preferred in Phase 1 and highest following the drug they had avoided. Preference was reassessed during the last 5 sessions of Phase 2. Five of the participants preferred placebo in Phase 1 but diazepam in Phase 2. Subjective responses to the drugs also changed across the 2 phases.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalExperimental and Clinical Psychopharmacology
Volume10
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

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