Exercise-Based cardiac rehabilitation modulates prefrontal cortex oxygenation during submaximal exercise testing in cardiovascular disease patients

Terence Moriarty; Kelsey Bourbeau; Christine Mermier; Len Kravitz; Ann Gibson; Nicholas Beltz; Omar Negrete; Micah Zuhl

doi:10.3390/BS10060104

Exercise-Based cardiac rehabilitation modulates prefrontal cortex oxygenation during submaximal exercise testing in cardiovascular disease patients

Terence Moriarty, Kelsey Bourbeau, Christine Mermier, Len Kravitz, Ann Gibson, Nicholas Beltz, Omar Negrete, Micah Zuhl

Health Sciences, School Of

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study was to investigate if prefrontal cortex (PFC) oxygenation during incremental exercise is altered among cardiovascular disease (CVD) patients who completed 6 weeks of exercise-based cardiac rehabilitation (CR). Nineteen (male = 14, female = 5; 65.5 ± 11.5 years) participants from an outpatient CR program were enrolled in the study. Each participant completed a submaximal graded treadmill evaluation at intake and again upon completion of 18 individualized CR sessions. Functional near-infrared spectroscopy (fNIRS) imaging was used to measure left- and right- PFC (LPFC and RPFC) oxygenation parameters during the submaximal exercise evaluations. Patients showed improvements in cardiorespiratory capacity (pre 5.5 ± 2.5 vs. post 6.9 ± 2.8 metabolic equivalents (METs)). A significant decrease in LPFC and RPFC oxygenation was observed during the post-CR exercise test compared to pre-CR. CVD patients enrolled in 6 weeks of CR showed significant improvements in functional capacity along with decreased cortical oxygenation during submaximal exercise. Exercise training may cause distribution of cortical resources to motor regions that support sustained exercise.

Original language	English
Article number	10060104
Journal	Behavioral Sciences
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/BS10060104
State	Published - Jun 23 2020

Keywords

Aerobic exercise
Cardiac rehabilitation
Cardiovascular disease
Oxygenation
Prefrontal cortex

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10.3390/BS10060104

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title = "Exercise-Based cardiac rehabilitation modulates prefrontal cortex oxygenation during submaximal exercise testing in cardiovascular disease patients",

abstract = "The purpose of this study was to investigate if prefrontal cortex (PFC) oxygenation during incremental exercise is altered among cardiovascular disease (CVD) patients who completed 6 weeks of exercise-based cardiac rehabilitation (CR). Nineteen (male = 14, female = 5; 65.5 ± 11.5 years) participants from an outpatient CR program were enrolled in the study. Each participant completed a submaximal graded treadmill evaluation at intake and again upon completion of 18 individualized CR sessions. Functional near-infrared spectroscopy (fNIRS) imaging was used to measure left- and right- PFC (LPFC and RPFC) oxygenation parameters during the submaximal exercise evaluations. Patients showed improvements in cardiorespiratory capacity (pre 5.5 ± 2.5 vs. post 6.9 ± 2.8 metabolic equivalents (METs)). A significant decrease in LPFC and RPFC oxygenation was observed during the post-CR exercise test compared to pre-CR. CVD patients enrolled in 6 weeks of CR showed significant improvements in functional capacity along with decreased cortical oxygenation during submaximal exercise. Exercise training may cause distribution of cortical resources to motor regions that support sustained exercise.",

keywords = "Aerobic exercise, Cardiac rehabilitation, Cardiovascular disease, Oxygenation, Prefrontal cortex",

author = "Terence Moriarty and Kelsey Bourbeau and Christine Mermier and Len Kravitz and Ann Gibson and Nicholas Beltz and Omar Negrete and Micah Zuhl",

note = "Funding Information: This research was supported by the University of New Mexico-New Mexico Research Grant. The authors gratefully acknowledge the patients who agreed to participate in this study and the staff of New Heart Center for Wellness, Fitness and Cardiac Rehabilitation, Albuquerque, NM, USA. Funding Information: Funding: This research was supported by the University of New Mexico—New Mexico Research Grant. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",

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doi = "10.3390/BS10060104",

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AU - Moriarty, Terence

AU - Bourbeau, Kelsey

AU - Mermier, Christine

AU - Kravitz, Len

AU - Gibson, Ann

AU - Beltz, Nicholas

AU - Negrete, Omar

AU - Zuhl, Micah

N1 - Funding Information: This research was supported by the University of New Mexico-New Mexico Research Grant. The authors gratefully acknowledge the patients who agreed to participate in this study and the staff of New Heart Center for Wellness, Fitness and Cardiac Rehabilitation, Albuquerque, NM, USA. Funding Information: Funding: This research was supported by the University of New Mexico—New Mexico Research Grant. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2020/6/23

Y1 - 2020/6/23

N2 - The purpose of this study was to investigate if prefrontal cortex (PFC) oxygenation during incremental exercise is altered among cardiovascular disease (CVD) patients who completed 6 weeks of exercise-based cardiac rehabilitation (CR). Nineteen (male = 14, female = 5; 65.5 ± 11.5 years) participants from an outpatient CR program were enrolled in the study. Each participant completed a submaximal graded treadmill evaluation at intake and again upon completion of 18 individualized CR sessions. Functional near-infrared spectroscopy (fNIRS) imaging was used to measure left- and right- PFC (LPFC and RPFC) oxygenation parameters during the submaximal exercise evaluations. Patients showed improvements in cardiorespiratory capacity (pre 5.5 ± 2.5 vs. post 6.9 ± 2.8 metabolic equivalents (METs)). A significant decrease in LPFC and RPFC oxygenation was observed during the post-CR exercise test compared to pre-CR. CVD patients enrolled in 6 weeks of CR showed significant improvements in functional capacity along with decreased cortical oxygenation during submaximal exercise. Exercise training may cause distribution of cortical resources to motor regions that support sustained exercise.

AB - The purpose of this study was to investigate if prefrontal cortex (PFC) oxygenation during incremental exercise is altered among cardiovascular disease (CVD) patients who completed 6 weeks of exercise-based cardiac rehabilitation (CR). Nineteen (male = 14, female = 5; 65.5 ± 11.5 years) participants from an outpatient CR program were enrolled in the study. Each participant completed a submaximal graded treadmill evaluation at intake and again upon completion of 18 individualized CR sessions. Functional near-infrared spectroscopy (fNIRS) imaging was used to measure left- and right- PFC (LPFC and RPFC) oxygenation parameters during the submaximal exercise evaluations. Patients showed improvements in cardiorespiratory capacity (pre 5.5 ± 2.5 vs. post 6.9 ± 2.8 metabolic equivalents (METs)). A significant decrease in LPFC and RPFC oxygenation was observed during the post-CR exercise test compared to pre-CR. CVD patients enrolled in 6 weeks of CR showed significant improvements in functional capacity along with decreased cortical oxygenation during submaximal exercise. Exercise training may cause distribution of cortical resources to motor regions that support sustained exercise.

KW - Aerobic exercise

KW - Cardiac rehabilitation

KW - Cardiovascular disease

KW - Oxygenation

KW - Prefrontal cortex

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JF - Behavioral Sciences

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ER -

Exercise-Based cardiac rehabilitation modulates prefrontal cortex oxygenation during submaximal exercise testing in cardiovascular disease patients

Abstract

Keywords

UN SDGs

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