TY - JOUR
T1 - Fatal acute encephalopathy in two siblings
T2 - A distinct hereditary entity?
AU - Prasun, Pankaj
AU - Stockton, David W.
PY - 2012/3/15
Y1 - 2012/3/15
N2 - Viral infections particularly the influenza infection can be associated with significant central nervous system complications. The encephalopathy associated with viral infection may not be necessarily due to invasion by the microorganism but rather the hypercytokinemic response of the host. Individuals with certain genetic background are postulated to be at risk of this complication. Recent works in this area are aiming to elucidate the molecular mechanism and genetic susceptibility of this condition. Familial cases of infection associated encephalopathy indicate strong hereditary predisposition in some individuals. We describe a family with two siblings who developed fatal acute encephalopathy following respiratory tract infection of likely viral etiology.
AB - Viral infections particularly the influenza infection can be associated with significant central nervous system complications. The encephalopathy associated with viral infection may not be necessarily due to invasion by the microorganism but rather the hypercytokinemic response of the host. Individuals with certain genetic background are postulated to be at risk of this complication. Recent works in this area are aiming to elucidate the molecular mechanism and genetic susceptibility of this condition. Familial cases of infection associated encephalopathy indicate strong hereditary predisposition in some individuals. We describe a family with two siblings who developed fatal acute encephalopathy following respiratory tract infection of likely viral etiology.
KW - Acute encephalopathy
KW - Cerebral edema
KW - Familial
KW - Fatal acute encephalopathy
KW - Genetic
KW - Infection associated encephalopathy
UR - http://www.scopus.com/inward/record.url?scp=84857057700&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2011.10.035
DO - 10.1016/j.jns.2011.10.035
M3 - Article
C2 - 22113181
AN - SCOPUS:84857057700
VL - 314
SP - 155
EP - 157
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1-2
ER -