TY - JOUR
T1 - Feeding during transfusion and the risk of necrotizing enterocolitis in preterm infants
AU - Bajaj, Monika
AU - Lulic-Botica, Mirjana
AU - Hanson, Amber
AU - Natarajan, Girija
N1 - Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Objective: To evaluate the effect of withholding feeds during transfusion on transfusion associated acute gut injury (TRAGI). Study design: Data were collected on 125 preterm infants before and after the practice of withholding feeds for 12–24 h during transfusion was instituted. Logistic regression was used to examine effects of withholding feeds on TRAGI rates. Results: A total of 19 (15%) infants developed NEC; 6/19 (32%) had TRAGI. Postnatal hydrocortisone use was associated with TRAGI (OR 8.97; 95% CI 1.17–68.46, p = 0.034). There was no difference in NEC rates (15.8 vs. 14.7%) and the proportions (22.2 vs. 40%) of TRAGI in the two time periods before and after instituting the standardized feeding regimen and practice of holding feeds during transfusion. Conclusion: No significant decrease was noted in the rates of TRAGI after feeds were withheld during transfusion. Further studies are warranted to explore the relationship between feeds during transfusion and NEC.
AB - Objective: To evaluate the effect of withholding feeds during transfusion on transfusion associated acute gut injury (TRAGI). Study design: Data were collected on 125 preterm infants before and after the practice of withholding feeds for 12–24 h during transfusion was instituted. Logistic regression was used to examine effects of withholding feeds on TRAGI rates. Results: A total of 19 (15%) infants developed NEC; 6/19 (32%) had TRAGI. Postnatal hydrocortisone use was associated with TRAGI (OR 8.97; 95% CI 1.17–68.46, p = 0.034). There was no difference in NEC rates (15.8 vs. 14.7%) and the proportions (22.2 vs. 40%) of TRAGI in the two time periods before and after instituting the standardized feeding regimen and practice of holding feeds during transfusion. Conclusion: No significant decrease was noted in the rates of TRAGI after feeds were withheld during transfusion. Further studies are warranted to explore the relationship between feeds during transfusion and NEC.
UR - http://www.scopus.com/inward/record.url?scp=85061210861&partnerID=8YFLogxK
U2 - 10.1038/s41372-019-0328-7
DO - 10.1038/s41372-019-0328-7
M3 - Article
C2 - 30723281
AN - SCOPUS:85061210861
SN - 0743-8346
VL - 39
SP - 540
EP - 546
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -