Fibrillary glomerulonephritis and renal failure in a child with systemic lupus erythematosus

Shina Menon, Xu Zeng, Rudolph Valentini

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Fibrillary glomerulonephritis (FGN) is a rare immune-mediated glomerulopathy characterized by randomly arranged immunoglobulin (Ig) deposits on electron microscopy. Only seven pediatric cases have been reported, and the incidence in adults is about 1.5%. A 12-year-old boy presented with systemic lupus erythematosus (SLE) with World Health Organization Class IV lupus nephritis. A repeat biopsy carried out due to a poor response to standard immunosuppressive therapy and worsening renal functions revealed diffuse proliferative glomerulonephritis with fibrillary deposits. Despite aggressive immunosuppression with plasmapheresis and rituximab, the patient developed end stage renal disease. This is an atypical pediatric case characterized by SLE-associated FGN and a poor prognosis.

Original languageEnglish
Pages (from-to)1577-1581
Number of pages5
JournalPediatric Nephrology
Volume24
Issue number8
DOIs
StatePublished - 2009

Keywords

  • Fibrillary glomerulonephritis
  • Lupus nephritis

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