Fibrinolytic parameters in children with noncatheter thrombosis: A pilot study

O. Alphan Kupesiz, Meera B. Chitlur, Wendy Hollon, Ozgun Tosun, Ronald Thomas, Indira Warrier, Jeanne M. Lusher, Madhvi Rajpurkar

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Although the incidence of pediatric thrombosis has increased over the last decade, noncatheter-related deep venous thrombosis (nCDVT) is rare in children. Congenital and acquired hypercoagulable states may play an important role in the pathogenesis of nCDVT. In this study, we evaluated fibrinolytic parameters by measuring individual concentrations of fibrinolytic proteins and by tissue factor initiated whole blood thromboelastography (TEG), in which a fibrin clot was lyzed by exogenously added tissue plasminogen activator (tPA). Children with nCDVT were compared with age and sex-matched controls. TAFI concentrations were significantly higher in the patient group but there was no difference in the PAI-1, tPA and lipoprotein (a) concentrations. Significantly decreased fibrinolysis was found on TEG in the patient group suggesting that hypofibrinolysis may play an important role in the pathogenesis of nCDVT in children. To our knowledge, this is the first pediatric study that has systematically evaluated the role of fibrinolysis in the pathogenesis of DVT. Given our results, the role of fibrinolysis in the pathogenesis of nCDVT in children should be further evaluated in larger studies.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalBlood Coagulation and Fibrinolysis
Volume21
Issue number4
DOIs
StatePublished - Jun 2010

Keywords

  • Fibrinolysis
  • Noncatheter-related thrombosis
  • Pediatric thrombosis
  • Thromboelastography

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