TY - JOUR
T1 - Fibrinolytic parameters in children with noncatheter thrombosis
T2 - A pilot study
AU - Kupesiz, O. Alphan
AU - Chitlur, Meera B.
AU - Hollon, Wendy
AU - Tosun, Ozgun
AU - Thomas, Ronald
AU - Warrier, Indira
AU - Lusher, Jeanne M.
AU - Rajpurkar, Madhvi
PY - 2010/6
Y1 - 2010/6
N2 - Although the incidence of pediatric thrombosis has increased over the last decade, noncatheter-related deep venous thrombosis (nCDVT) is rare in children. Congenital and acquired hypercoagulable states may play an important role in the pathogenesis of nCDVT. In this study, we evaluated fibrinolytic parameters by measuring individual concentrations of fibrinolytic proteins and by tissue factor initiated whole blood thromboelastography (TEG), in which a fibrin clot was lyzed by exogenously added tissue plasminogen activator (tPA). Children with nCDVT were compared with age and sex-matched controls. TAFI concentrations were significantly higher in the patient group but there was no difference in the PAI-1, tPA and lipoprotein (a) concentrations. Significantly decreased fibrinolysis was found on TEG in the patient group suggesting that hypofibrinolysis may play an important role in the pathogenesis of nCDVT in children. To our knowledge, this is the first pediatric study that has systematically evaluated the role of fibrinolysis in the pathogenesis of DVT. Given our results, the role of fibrinolysis in the pathogenesis of nCDVT in children should be further evaluated in larger studies.
AB - Although the incidence of pediatric thrombosis has increased over the last decade, noncatheter-related deep venous thrombosis (nCDVT) is rare in children. Congenital and acquired hypercoagulable states may play an important role in the pathogenesis of nCDVT. In this study, we evaluated fibrinolytic parameters by measuring individual concentrations of fibrinolytic proteins and by tissue factor initiated whole blood thromboelastography (TEG), in which a fibrin clot was lyzed by exogenously added tissue plasminogen activator (tPA). Children with nCDVT were compared with age and sex-matched controls. TAFI concentrations were significantly higher in the patient group but there was no difference in the PAI-1, tPA and lipoprotein (a) concentrations. Significantly decreased fibrinolysis was found on TEG in the patient group suggesting that hypofibrinolysis may play an important role in the pathogenesis of nCDVT in children. To our knowledge, this is the first pediatric study that has systematically evaluated the role of fibrinolysis in the pathogenesis of DVT. Given our results, the role of fibrinolysis in the pathogenesis of nCDVT in children should be further evaluated in larger studies.
KW - Fibrinolysis
KW - Noncatheter-related thrombosis
KW - Pediatric thrombosis
KW - Thromboelastography
UR - http://www.scopus.com/inward/record.url?scp=77951907393&partnerID=8YFLogxK
U2 - 10.1097/MBC.0b013e32833464ce
DO - 10.1097/MBC.0b013e32833464ce
M3 - Article
C2 - 20305541
AN - SCOPUS:77951907393
VL - 21
SP - 313
EP - 319
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
SN - 0957-5235
IS - 4
ER -