Formic acid: A low-cost, mild, ecofriendly, and highly efficient catalyst for the rapid synthesis of β-enaminones

Siddappa A. Patil, Phillip A. Medina, Diego Gonzalez-Flores, Jason K. Vohs, Seth Dever, Leslie W. Pineda, Mavis L. Montero, Bradley D. Fahlman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

β-Enaminones have been synthesized by the condensation reaction of b-diketones with various anilines in the presence of a catalytic amount of formic acid, mild and highly efficient acid catalyst in methanol. These condensation reactions proceed smoothly in short reaction times with near-quantitative yields.

Original languageEnglish
Pages (from-to)2349-2364
Number of pages16
JournalSynthetic Communications
Volume43
Issue number17
DOIs
StatePublished - Sep 2 2013

Keywords

  • Crystal structure
  • Formic acid
  • Synthesis
  • β-enaminone

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