TY - JOUR
T1 - Four-dimensional tractography animates propagations of neural activation via distinct interhemispheric pathways
AU - Mitsuhashi, Takumi
AU - Sonoda, Masaki
AU - Jeong, Jeong won
AU - Silverstein, Brian H.
AU - Iwaki, Hirotaka
AU - Luat, Aimee F.
AU - Sood, Sandeep
AU - Asano, Eishi
N1 - Funding Information:
We are grateful to Karin Halsey, BS, REEGT. and Jamie MacDougall, RN, BSN, CPN at Children's Hospital of Michigan for the collaboration and assistance in performing the studies described above. This work was supported by the National Institutes of Health [grant number: NS064033 (to E.A.); NS089659 (to J.W.J.)] and JST CREST [grant number: JPMJCR1784 (to T.M.)]. None of the authors have potential conflicts of interest to be disclosed.
Funding Information:
We are grateful to Karin Halsey, BS, REEGT. and Jamie MacDougall, RN, BSN, CPN at Children's Hospital of Michigan for the collaboration and assistance in performing the studies described above. This work was supported by the National Institutes of Health [grant number: NS064033 (to E.A.); NS089659 (to J.W.J.)] and JST CREST [grant number: JPMJCR1784 (to T.M.)].
Publisher Copyright:
© 2020 International Federation of Clinical Neurophysiology
PY - 2021/2
Y1 - 2021/2
N2 - Objective: To visualize and validate the dynamics of interhemispheric neural propagations induced by single-pulse electrical stimulation (SPES). Methods: This methodological study included three patients with drug-resistant focal epilepsy who underwent measurement of cortico-cortical spectral responses (CCSRs) during bilateral stereo-electroencephalography recording. We delivered SPES to 83 electrode pairs and analyzed CCSRs recorded at 268 nonepileptic electrode sites. Diffusion-weighted imaging (DWI) tractography localized the interhemispheric white matter pathways as streamlines directly connecting two electrode sites. We localized and visualized the putative SPES-related fiber activation, at each 1-ms time window, based on the propagation velocity defined as the DWI-based streamline length divided by the early CCSR peak latency. Results: The resulting movie, herein referred to as four-dimensional tractography, delineated the spatiotemporal dynamics of fiber activation via the corpus callosum and anterior commissure. Longer streamline length was associated with delayed peak latency and smaller amplitude of CCSRs. The cortical regions adjacent to each fiber activation site indeed exhibited CCSRs at the same time window. Conclusions: Our four-dimensional tractography successfully animated neural propagations via distinct interhemispheric pathways. Significance: Our novel animation method has the potential to help investigators in addressing the mechanistic significance of the interhemispheric network dynamics supporting physiological function.
AB - Objective: To visualize and validate the dynamics of interhemispheric neural propagations induced by single-pulse electrical stimulation (SPES). Methods: This methodological study included three patients with drug-resistant focal epilepsy who underwent measurement of cortico-cortical spectral responses (CCSRs) during bilateral stereo-electroencephalography recording. We delivered SPES to 83 electrode pairs and analyzed CCSRs recorded at 268 nonepileptic electrode sites. Diffusion-weighted imaging (DWI) tractography localized the interhemispheric white matter pathways as streamlines directly connecting two electrode sites. We localized and visualized the putative SPES-related fiber activation, at each 1-ms time window, based on the propagation velocity defined as the DWI-based streamline length divided by the early CCSR peak latency. Results: The resulting movie, herein referred to as four-dimensional tractography, delineated the spatiotemporal dynamics of fiber activation via the corpus callosum and anterior commissure. Longer streamline length was associated with delayed peak latency and smaller amplitude of CCSRs. The cortical regions adjacent to each fiber activation site indeed exhibited CCSRs at the same time window. Conclusions: Our four-dimensional tractography successfully animated neural propagations via distinct interhemispheric pathways. Significance: Our novel animation method has the potential to help investigators in addressing the mechanistic significance of the interhemispheric network dynamics supporting physiological function.
KW - Dynamic tractography
KW - Effective connectivity
KW - Functional brain mapping
KW - Pediatric epilepsy surgery
KW - cortico-cortical evoked potentials (CCEPs)
KW - electrocorticography (ECoG)
UR - http://www.scopus.com/inward/record.url?scp=85099253051&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2020.11.030
DO - 10.1016/j.clinph.2020.11.030
M3 - Article
C2 - 33450573
AN - SCOPUS:85099253051
VL - 132
SP - 520
EP - 529
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 2
ER -