TY - JOUR
T1 - Gastric adenocarcinoma
T2 - The role of helicobacter pylori in pathogenesis and prevention efforts
AU - Laird-Fick, Heather S.
AU - Saini, Shivani
AU - Hillard, James Randolph
N1 - Publisher Copyright:
© 2016, BMJ Publishing Group. All rights reserved.
PY - 2016/8
Y1 - 2016/8
N2 - Gastric cancer is the third most common cause of cancer deaths in the world, prompting high-risk countries like South Korea and Japan to establish nationwide screening programmes. Helicobacter pylori is linked to the majority of gastric adenocarcinoma cases and to the vast majority of non-cardia gastric adenocarcinomas. Several studies have demonstrated the effectiveness of ‘test-and-treat’ programmes for H. pylori infection to prevent gastric cancer in high-risk populations. While this strategy has gained momentum, providers in low-risk developed countries may be unaware of the risk individual patients face, particularly those who have emigrated from high-risk regions and members of economically disadvantaged minority groups. Rapidly evolving science in recent years has made it difficult for clinicians to keep up with the current best practices. This article reviews the epidemiology of H. pylori and gastric cancer, screening and diagnostic tests and the current treatment regimens for clinicians.
AB - Gastric cancer is the third most common cause of cancer deaths in the world, prompting high-risk countries like South Korea and Japan to establish nationwide screening programmes. Helicobacter pylori is linked to the majority of gastric adenocarcinoma cases and to the vast majority of non-cardia gastric adenocarcinomas. Several studies have demonstrated the effectiveness of ‘test-and-treat’ programmes for H. pylori infection to prevent gastric cancer in high-risk populations. While this strategy has gained momentum, providers in low-risk developed countries may be unaware of the risk individual patients face, particularly those who have emigrated from high-risk regions and members of economically disadvantaged minority groups. Rapidly evolving science in recent years has made it difficult for clinicians to keep up with the current best practices. This article reviews the epidemiology of H. pylori and gastric cancer, screening and diagnostic tests and the current treatment regimens for clinicians.
UR - http://www.scopus.com/inward/record.url?scp=84973334060&partnerID=8YFLogxK
U2 - 10.1136/postgradmedj-2016-133997
DO - 10.1136/postgradmedj-2016-133997
M3 - Review article
C2 - 27222587
AN - SCOPUS:84973334060
VL - 92
SP - 471
EP - 477
JO - Postgraduate Medical Journal
JF - Postgraduate Medical Journal
SN - 0032-5473
IS - 1090
ER -