TY - JOUR
T1 - Gender and alcohol moderate caregiver reported child behavior after prenatal cocaine
AU - Sood, Beena G.
AU - Nordstrom Bailey, Beth
AU - Covington, Chandice
AU - Sokol, Robert J.
AU - Ager, Joel
AU - Janisse, James
AU - Hannigan, John H.
AU - Delaney-Black, Virginia
N1 - Funding Information:
Funding and support for this project were provided by NIDA R01 DA08524 to VDB, NIH K23 HD41423 to BGS, and the Helppie Institute for Urban Pediatric Health Research, Children's Research Center of Michigan, Children's Hospital of Michigan.
PY - 2005
Y1 - 2005
N2 - Objective: The concurrence of prenatal alcohol exposure with other drug exposure, low socioeconomic status and environmental risk factors may obscure associations, if any, between prenatal cocaine exposure and child outcomes. This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses stratified by gender and prenatal alcohol exposure status. Methods: Maternal alcohol, cigarette, and illicit drug use were prospectively assessed by interview during pregnancy and postnatally. Maternal and neonatal urine were tested for drug exposure as clinically indicated. Caregiver report of child behavior was assessed with the Achenbach Child Behavior Checklist (CBCL). Dichotomous cocaine exposure was characterized as no (negative history and biologic markers), and any (positive history and/or biologic markers during pregnancy and/or positive urine screen at delivery from either mother or infant). Results: Prenatal cocaine exposure was associated with adverse effects on offspring behavior that were moderated by the gender of the offspring as well as prenatal alcohol exposure. For girls without prenatal alcohol exposure, 6.5% of the unique variance in behavior was related to prenatal cocaine exposure. For these girls, the odds of scoring in the abnormal range for Aggression was 17 times control levels (95% confidence limits 1.4 to 203). These findings, though significant, have wide confidence intervals and need to be replicated in larger cohorts and on longitudinal follow-up.
AB - Objective: The concurrence of prenatal alcohol exposure with other drug exposure, low socioeconomic status and environmental risk factors may obscure associations, if any, between prenatal cocaine exposure and child outcomes. This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses stratified by gender and prenatal alcohol exposure status. Methods: Maternal alcohol, cigarette, and illicit drug use were prospectively assessed by interview during pregnancy and postnatally. Maternal and neonatal urine were tested for drug exposure as clinically indicated. Caregiver report of child behavior was assessed with the Achenbach Child Behavior Checklist (CBCL). Dichotomous cocaine exposure was characterized as no (negative history and biologic markers), and any (positive history and/or biologic markers during pregnancy and/or positive urine screen at delivery from either mother or infant). Results: Prenatal cocaine exposure was associated with adverse effects on offspring behavior that were moderated by the gender of the offspring as well as prenatal alcohol exposure. For girls without prenatal alcohol exposure, 6.5% of the unique variance in behavior was related to prenatal cocaine exposure. For these girls, the odds of scoring in the abnormal range for Aggression was 17 times control levels (95% confidence limits 1.4 to 203). These findings, though significant, have wide confidence intervals and need to be replicated in larger cohorts and on longitudinal follow-up.
KW - Child Behavior Checklist (CBCL)
KW - Child behavior
KW - Cocaine
KW - Prenatal exposure delayed effects
UR - http://www.scopus.com/inward/record.url?scp=14044270619&partnerID=8YFLogxK
U2 - 10.1016/j.ntt.2004.10.005
DO - 10.1016/j.ntt.2004.10.005
M3 - Article
C2 - 15734270
AN - SCOPUS:14044270619
VL - 27
SP - 191
EP - 201
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
SN - 0892-0362
IS - 2
ER -