Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia

Holly Edwards, Mara Rubenstein, Alan A. Dombkowski, J. Timothy Caldwell, Roland Chu, Ana C. Xavier, Ryan Thummel, Melody Neely, Larry H. Matherly, Yubin Ge, Jeffrey W. Taub

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


In this study we sought to identify genetic factors associated with the presenting white blood cell (WBC) count in B-precursor acute lymphoblastic leukemia (BP-ALL). Using ETV6- RUNX1-positive BP-ALL patient samples, a homogeneous subtype, we identified 16 differentially expressed genes based on the presenting WBC count (< 50,000/cumm vs > 50,000). We further confirmed that IL1R1, BCAR3, KCNH2, PIR, and ZDHHC23 were differentially expressed in a larger cohort of ETV6-RUNX1-negative BP-ALL patient samples. Statistical analysis demonstrated that expression levels of these genes could accurately categorize high and low WBC count subjects using two independent patient sets, representing positive and negative ETV6-RUNX1 cases. Further studies in leukemia cell line models will better delineate the role of these genes in regulating the white blood cell count and potentially identify new therapeutic targets.

Original languageEnglish
Article numbere0161539
JournalPLoS ONE
Issue number8
StatePublished - Aug 2016


Dive into the research topics of 'Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia'. Together they form a unique fingerprint.

Cite this